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Volume 11, Issue 2 (May 2026)
JNFS 2026, 11(2): 178-190 |
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Goodarzi S, Mirjalili F, Forootani B, Yekrang Safakar H, Salehi-Abargouei A. Polyphenol Intake and the Risk of Pancreatic Cancer: A Systematic Review and Meta-analysis of Observational Studies. JNFS 2026; 11 (2) :178-190
URL: http://jnfs.ssu.ac.ir/article-1-1291-en.html
URL: http://jnfs.ssu.ac.ir/article-1-1291-en.html
Sima Goodarzi 
, Fatemeh Mirjalili , Bita Forootani , Hooman Yekrang Safakar , Amin Salehi-Abargouei *
, Fatemeh Mirjalili , Bita Forootani , Hooman Yekrang Safakar , Amin Salehi-Abargouei *
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (800 Views)
Background: Considering the antioxidant effects of polyphenols, it remains unclear whether dietary polyphenols can affect the risk of pancreatic cancer. This study assessed the association between polyphenol intake and the risk of pancreatic cancer. Methods: Articles published until April 2023 in PubMed, Scopus, and the Web of Science (ISI) were searched. Observational studies on the association between dietary polyphenol intake and the odds of pancreatic cancer were also included. Odds ratios (ORs) with 95% confidence intervals (CIs) were used as effect sizes. Furthermore, standard methods were used to evaluate the heterogeneity, sensitivity, and publication bias. The Newcastle-Ottawa Scale (NOS) was used for quality assessment. Results: Eight studies were included. Although this systematic review and meta-analysis revealed no relationship between the intake of total flavonoids, flavan-3-ols, flavones, flavonols, flavanones, anthocyanidins, and pancreatic cancer odds; in qualitative analysis, a positive relationship was observed between genistein and the aflavin intake and pancreatic cancer risk. Conclusions: No relationship was observed between polyphenol intake and pancreatic cancer odds. Polyphenols have poor bioavailability and bioaccessibility, which may have affected their results. Therefore, more high-quality studies with precise designs are required to determine whether a relationship exists.
Type of article: review article |
Subject:
public specific
Received: 2025/03/10 | Published: 2026/05/30 | ePublished: 2026/05/30
Received: 2025/03/10 | Published: 2026/05/30 | ePublished: 2026/05/30
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