Journal of Nutrition and Food Security

en Polyphenol Intake and the Risk of Pancreatic Cancer: A Systematic Review and Meta-analysis of Observational Studies public specific review article <div style="text-align: justify;">Background: Considering the antioxidant effects of polyphenols, it remains unclear whether dietary polyphenols can affect the risk of pancreatic cancer. This study assessed the association between polyphenol intake and the risk of pancreatic cancer. Methods: Articles<a name="_Hlk171797771"> published until April 2023 in PubMed, Scopus, and the Web of Science (ISI) were searched.</a> Observational studies on the association between dietary polyphenol intake and the odds of pancreatic cancer were also included. Odds ratios (ORs) with 95% confidence intervals (CIs) were used as effect sizes. Furthermore, standard methods were used to evaluate the heterogeneity, sensitivity, and publication bias. The Newcastle-Ottawa Scale (NOS) was used for quality assessment. Results: Eight studies were included. Although this systematic review and meta-analysis revealed no relationship between the intake of total flavonoids, flavan-3-ols, flavones, flavonols, flavanones, anthocyanidins, and pancreatic cancer odds; in qualitative analysis, a positive relationship was observed between genistein and the aflavin intake and pancreatic cancer risk. Conclusions: No relationship was observed between polyphenol intake and pancreatic cancer odds. Polyphenols have poor bioavailability and bioaccessibility, which may have affected their results. Therefore, more high-quality studies with precise designs are required to determine whether a relationship exists.</div> Polyphenol, Flavonoid, Pancreatic cancer, Observational studies 178 190 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-1388-1&slc_lang=en&sid=1 Sima Goodarzi No Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatemeh Mirjalili No Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Bita Forootani No Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hooman Yekrang Safakar No Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Amin Salehi-Abargouei Yes Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran