دوره 10، شماره 2 - ( 3-1404 )
جلد 10 شماره 2 صفحات 203-194 |
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Faghfouri A H, Seyyed Shoura S M, shahhosseini G, Khodabandehloo A A, Fathollahia P, Khabbazi A, et al . Effect of Zinc Gluconate Supplementation on C-Reactive Protein and Malondialdehyde in Patients with Behcet's Disease: A Double-Blind Randomized Controlled Clinical Trial. J Nutr Food Secur. 2025; 10 (2) :194-203
URL: http://jnfs.ssu.ac.ir/article-1-1063-fa.html
URL: http://jnfs.ssu.ac.ir/article-1-1063-fa.html
Effect of Zinc Gluconate Supplementation on C-Reactive Protein and Malondialdehyde in Patients with Behcet's Disease: A Double-Blind Randomized Controlled Clinical Trial. Journal of Nutrition and Food Security. 1404; 10 (2) :194-203
چکیده: (2175 مشاهده)
Background: Behçet's disease (BD) with autoimmune and auto-inflammatory nature is more prevalent in Silk Road countries. The current study aimed to investigate the effect of zinc gluconate supplementation on C-reactive protein (CRP) and malondialdehyde (MDA) levels in BD patients. Methods: This randomized controlled clinical trial was conducted on 50 Iranian BD patients. Participants were randomly assigned into either placebo or zinc gluconate (30 mg/day) groups for 12 weeks. Before and after the intervention, serum MDA and CRP levels were measured. Results: Zinc supplementation led to a significant increase in serum zinc levels compared to the placebo group (P<0.05). There was no significant difference in MDA serum levels between the groups after adjusting for the baseline values and confounding factors (P>0.05). Zinc supplementation led to a significant improvement in CRP serum levels compared to the placebo group following adjustment for the effect of baseline values and confounding factors (P=0.012 and 0.04, respectively). Conclusion: Zinc supplementation in an elemental dose of 30 mg per day has an anti-inflammatory effect in BD patients by reducing CRP levels. The beneficial effect of zinc on lipid peroxidation in BD patients was not shown in the study.
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