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Volume 10, Issue 2 (May 2025)
JNFS 2025, 10(2): 194-203 |
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Faghfouri A H, Seyyed Shoura S M, shahhosseini G, Khodabandehloo A A, Fathollahia P, Khabbazi A, et al . Effect of Zinc Gluconate Supplementation on C-Reactive Protein and Malondialdehyde in Patients with Behcet's Disease: A Double-Blind Randomized Controlled Clinical Trial. JNFS 2025; 10 (2) :194-203
URL: http://jnfs.ssu.ac.ir/article-1-1063-en.html
URL: http://jnfs.ssu.ac.ir/article-1-1063-en.html
Amir Hossein Faghfouri 
, Seyyed Morteza Seyyed Shoura , Ghazaleh Shahhosseini , Amir Arshia Khodabandehloo , Pourya Fathollahia , Alireza Khabbazi , Vali Musazadeh , Beitullah Alipour *
, Seyyed Morteza Seyyed Shoura , Ghazaleh Shahhosseini , Amir Arshia Khodabandehloo , Pourya Fathollahia , Alireza Khabbazi , Vali Musazadeh , Beitullah Alipour *
Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: (504 Views)
Background: Behçet's disease (BD) with autoimmune and auto-inflammatory nature is more prevalent in Silk Road countries. The current study aimed to investigate the effect of zinc gluconate supplementation on C-reactive protein (CRP) and malondialdehyde (MDA) levels in BD patients. Methods: This randomized controlled clinical trial was conducted on 50 Iranian BD patients. Participants were randomly assigned into either placebo or zinc gluconate (30 mg/day) groups for 12 weeks. Before and after the intervention, serum MDA and CRP levels were measured. Results: Zinc supplementation led to a significant increase in serum zinc levels compared to the placebo group (P<0.05). There was no significant difference in MDA serum levels between the groups after adjusting for the baseline values and confounding factors (P>0.05). Zinc supplementation led to a significant improvement in CRP serum levels compared to the placebo group following adjustment for the effect of baseline values and confounding factors (P=0.012 and 0.04, respectively). Conclusion: Zinc supplementation in an elemental dose of 30 mg per day has an anti-inflammatory effect in BD patients by reducing CRP levels. The beneficial effect of zinc on lipid peroxidation in BD patients was not shown in the study.
Type of article: orginal article |
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public specific
Received: 2024/05/17 | Published: 2025/05/30 | ePublished: 2025/05/30
Received: 2024/05/17 | Published: 2025/05/30 | ePublished: 2025/05/30
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