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Volume 8, Issue 4 (Nov 2023)
JNFS 2023, 8(4): 565-576 |
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Sadeghi Nodoushan F, Hakimian F, Haghiralsadat B F, Taghiyar S. The Effect of Superparamagnetic Fe3O4 Nanoparticles Combined with Quercetin on Breast Cancer Cell Line (MCF-7). JNFS 2023; 8 (4) :565-576
URL: http://jnfs.ssu.ac.ir/article-1-893-en.html
URL: http://jnfs.ssu.ac.ir/article-1-893-en.html
Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (503 Views)
Background: Magnetic nanoparticles attract increasing interest due to their use in cancer therapy and as drug carriers for several other diseases. The present study investigates the physiochemical properties of quercetin-conjugated superparamagnetic Fe3O4 nanoparticles and their effects on breast cancer cell line MCF-7. Methods: A simple precipitation method was used to prepare the Poly Ethylene Imine (PEI)-coated Fe3O4 nanoparticles; they were then conjugated with flavonoid-compound quercetin on the surface via carboxylic/amine group using nanoprecipitation method. Then, the physical and chemical parameters were calculated using Zeta-sizer, scanning electron microscopy (SEM), and extract release patterns at 37 and 42 0C. Finally, the toxicity level of this quercetin- conjugated nanosystem on the MCF-7 cells was investigated by MTT assay. Results: The results showed that the prepared nanosystem attained about 74% of quercetin inclusion, 91.2 nm size, 65.1 mV zeta potential, spherical morphology and a controlled release. Compared to Fe3O4 nanoparticles and pure quercetin, MTT and microscopy analysis revealed that quercetin-conjugated Fe3O4 nanoparticles induced considerable cytotoxicity, and morphology changes against MCF7 cells. Conclusion: Quercetin-conjugated Fe3O4 nanoparticles have appropriate physiochemical properties; they can be a suitable carrier for drug delivery and a promising therapy for candidates.
Corresponding Author:Bibi Fatemeh Haghiralsadat
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Corresponding Author:Bibi Fatemeh Haghiralsadat
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You can search for this author in PubMed Google Scholar Profile
Type of article: orginal article |
Subject:
public specific
Received: 2023/05/13 | Published: 2023/11/20 | ePublished: 2023/11/20
Received: 2023/05/13 | Published: 2023/11/20 | ePublished: 2023/11/20
References
1. áO'Connor CJ 2012. One-pot synthesis in polyamines for preparation of water-soluble magnetite nanoparticles with amine surface reactivity. Journal of Materials Chemistry. 22 (8): 3311-3313.
2. Badruddoza A, Junwen L, Hidajat K & Uddin M 2012. Selective recognition and separation of nucleosides using carboxymethyl-β-cyclodextrin functionalized hybrid magnetic nanoparticles. Colloids and surfaces B: Biointerfaces. 92: 223-231.
3. Bhalla Y, Gupta VK & Jaitak V 2013. Anticancer activity of essential oils: a review. Journal of the science of food and agriculture. 93 (15): 3643-3653.
4. Engineer C, Parikh J & Raval A 2011. Review on hydrolytic degradation behavior of biodegradable polymers from controlled drug delivery system. Trends in biomaterials & artificial organs. 25 (2).
5. Haghiralsadat F, et al. 2016. Strategy of Improvements in the rapeutic index of medicinal herbs of Iranianin digenous: Synthesis and characterization of phospholipid lipid-based vesicles in corporated Trachyspermum copticum. Shohid Sadoughi University Journal. 24 (6): 468-478.
6. Hakimian F, Haghiralsadat BF, Hadian-Ghazvini S, Azizi M & Ghourchian H 2023. Fe3O4/Au/porous Au nanohybrid for efficient delivery of doxorubicin as a model drug. Microchimica Acta. 190 (3): 102.
7. Horton LM, Kim K, Kothaneth S & Amelink CT 2011. Macroergonomic analysis of instructional technology adoption: a case study on tablet PC adoption. In 2011 ASEE Annual Conference & Exposition, pp. 22.1030. 1031-1022.1030. 1017.
8. Jia Y, et al. 2012. Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery. International journal of nanomedicine. 7: 1697-1708.
9. Kakran M, Sahoo N & Li L 2011. Dissolution enhancement of quercetin through nanofabrication, complexation, and solid dispersion. Colloids and surfaces B: Biointerfaces. 88 (1): 121-130.
10. Kievit FM & Zhang M 2011. Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers. Advanced materials. 23 (36): H217-H247.
11. Kumar SR, et al. 2014. Quercetin conjugated superparamagnetic magnetite nanoparticles for in-vitro analysis of breast cancer cell lines for chemotherapy applications. Journal of colloid and interface science. 436: 234-242.
12. Kumari A, Yadav SK, Pakade YB, Singh B & Yadav SC 2010. Development of biodegradable nanoparticles for delivery of quercetin. Colloids and Surfaces B: Biointerfaces. 80 (2): 184-192.
13. Lopes KP, et al. 2020. Binary Micelles (E 45 S 8/F127) for Quercetin and Griseofulvin Solubilisation. Química Nova. 43: 1011-1016.
14. Majdizadeh M, et al. 2018. A new strategy in improving therapeutic indexes of medicinal herbs: preparation and characterization of nano-liposomes containing Mentha piperita essential oil. Shahid Sadoughi University Journal. 25 (11): 853-864.
15. Ramar M, et al. 2015. Synthesis of silver nanoparticles using Solanum trilobatum fruits extract and its antibacterial, cytotoxic activity against human breast cancer cell line MCF 7. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 140: 223-228.
16. Rasoulian-broujeni M, Najafi S & Hojati-Emami S 2011. Dehghan mohammad mehdi. Preparation and evaluation of nanoparticles containing oxaliplatin for target drug release at the site of breast tumor. Iranian journal of breast diseases. 4 (3): 33-43.
17. Reddy LH, Arias JL, Nicolas J & Couvreur P 2012. Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chemical reviews. 112 (11): 5818-5878.
18. Revia RA & Zhang M 2016. Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. Materials today. 19 (3): 157-168.
19. Sun H, Jiao X, Han Y, Jiang Z & Chen D 2013. Synthesis of Fe3O4‐Au Nanocomposites with Enhanced Peroxidase‐Like Activity. European journal of inorganic chemistry. 2013 (1): 109-114.
20. Wang W, et al. 2016. The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review. Trends in food science & technology. 56: 21-38.
21. Yang M, et al. 2020. A novel synthesis of Fe3O4@ SiO2@ Au@ Porous SiO2 structure for NIR irradiation-induced DOX release and cancer treatment. Dose-Response. 18 (1): 1559325820906662.
22. Yazdani F & Seddigh M 2016. Magnetite nanoparticles synthesized by co-precipitation method: The effects of various iron anions on specifications. Materials chemistry and physics. 184: 318-323.
23. Zhao N, et al. 2020. Teamed boronate affinity-functionalized branched polyethyleneimine-modified magnetic nanoparticles for the selective capture of ginsenosides from rat plasma. Chemical engineering journal. 383: 123079.
24. áO'Connor CJ 2012. One-pot synthesis in polyamines for preparation of water-soluble magnetite nanoparticles with amine surface reactivity. Journal of Materials Chemistry. 22 (8): 3311-3313.
25. Badruddoza A, Junwen L, Hidajat K & Uddin M 2012. Selective recognition and separation of nucleosides using carboxymethyl-β-cyclodextrin functionalized hybrid magnetic nanoparticles. Colloids and surfaces B: Biointerfaces. 92: 223-231.
26. Bhalla Y, Gupta VK & Jaitak V 2013. Anticancer activity of essential oils: a review. Journal of the science of food and agriculture. 93 (15): 3643-3653.
27. Engineer C, Parikh J & Raval A 2011. Review on hydrolytic degradation behavior of biodegradable polymers from controlled drug delivery system. Trends in biomaterials & artificial organs. 25 (2).
28. Haghiralsadat F, et al. 2016. Strategy of Improvements in the rapeutic index of medicinal herbs of Iranianin digenous: Synthesis and characterization of phospholipid lipid-based vesicles in corporated Trachyspermum copticum. Shohid Sadoughi University Journal. 24 (6): 468-478.
29. Hakimian F, Haghiralsadat BF, Hadian-Ghazvini S, Azizi M & Ghourchian H 2023. Fe3O4/Au/porous Au nanohybrid for efficient delivery of doxorubicin as a model drug. Microchimica Acta. 190 (3): 102.
30. Horton LM, Kim K, Kothaneth S & Amelink CT 2011. Macroergonomic analysis of instructional technology adoption: a case study on tablet PC adoption. In 2011 ASEE Annual Conference & Exposition, pp. 22.1030. 1031-1022.1030. 1017.
31. Jia Y, et al. 2012. Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery. International journal of nanomedicine. 7: 1697-1708.
32. Kakran M, Sahoo N & Li L 2011. Dissolution enhancement of quercetin through nanofabrication, complexation, and solid dispersion. Colloids and surfaces B: Biointerfaces. 88 (1): 121-130.
33. Kievit FM & Zhang M 2011. Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers. Advanced materials. 23 (36): H217-H247.
34. Kumar SR, et al. 2014. Quercetin conjugated superparamagnetic magnetite nanoparticles for in-vitro analysis of breast cancer cell lines for chemotherapy applications. Journal of colloid and interface science. 436: 234-242.
35. Kumari A, Yadav SK, Pakade YB, Singh B & Yadav SC 2010. Development of biodegradable nanoparticles for delivery of quercetin. Colloids and Surfaces B: Biointerfaces. 80 (2): 184-192.
36. Lopes KP, et al. 2020. Binary Micelles (E 45 S 8/F127) for Quercetin and Griseofulvin Solubilisation. Química Nova. 43: 1011-1016.
37. Majdizadeh M, et al. 2018. A new strategy in improving therapeutic indexes of medicinal herbs: preparation and characterization of nano-liposomes containing Mentha piperita essential oil. Shahid Sadoughi University Journal. 25 (11): 853-864.
38. Ramar M, et al. 2015. Synthesis of silver nanoparticles using Solanum trilobatum fruits extract and its antibacterial, cytotoxic activity against human breast cancer cell line MCF 7. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 140: 223-228.
39. Rasoulian-broujeni M, Najafi S & Hojati-Emami S 2011. Dehghan mohammad mehdi. Preparation and evaluation of nanoparticles containing oxaliplatin for target drug release at the site of breast tumor. Iranian journal of breast diseases. 4 (3): 33-43.
40. Reddy LH, Arias JL, Nicolas J & Couvreur P 2012. Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chemical reviews. 112 (11): 5818-5878.
41. Revia RA & Zhang M 2016. Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. Materials today. 19 (3): 157-168.
42. Sun H, Jiao X, Han Y, Jiang Z & Chen D 2013. Synthesis of Fe3O4‐Au Nanocomposites with Enhanced Peroxidase‐Like Activity. European journal of inorganic chemistry. 2013 (1): 109-114.
43. Wang W, et al. 2016. The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review. Trends in food science & technology. 56: 21-38.
44. Yang M, et al. 2020. A novel synthesis of Fe3O4@ SiO2@ Au@ Porous SiO2 structure for NIR irradiation-induced DOX release and cancer treatment. Dose-Response. 18 (1): 1559325820906662.
45. Yazdani F & Seddigh M 2016. Magnetite nanoparticles synthesized by co-precipitation method: The effects of various iron anions on specifications. Materials chemistry and physics. 184: 318-323.
46. Zhao N, et al. 2020. Teamed boronate affinity-functionalized branched polyethyleneimine-modified magnetic nanoparticles for the selective capture of ginsenosides from rat plasma. Chemical engineering journal. 383: 123079
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