Volume 9, Issue 1 (Feb 2024)                   JNFS 2024, 9(1): 92-103 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Veysi Z, Dehghani A, Sanjari M, Maghbooli Z, Mirzaei K. Interaction of Vitamin D Receptor Gene FokI Variants and Omega-3 Fatty Acids on Perceived Stress Score and Serum Cortisol Levels in Nurses: A Cross-Sectional Study. JNFS 2024; 9 (1) :92-103
URL: http://jnfs.ssu.ac.ir/article-1-782-en.html
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (608 Views)
There is a high prevalence of perceived stress among nurses. Recent studies have shown that omega-3 fatty acids and genetic variants contribute to perceived stress. This study aimed to examine interactions between vitamin D receptor (VDR) gene FokI polymorphism and omega-3 fatty acids on perceived stress score and serum cortisol levels in nurses. Methods: A total of 268 Iranian nurses (248 women; 20 men) participated in this cross-sectional study. Omega-3 fatty acids and perceived stress score of participants were evaluated using a 3-day food record and the Perceived Stress Scale (PSS)-10, respectively. Serum cortisol concentrations were evaluated by ELISA. VDR FokI polymorphism was genotyped using the restriction fragment length polymorphism method. Results: No significant relationship was found between omega-3 fatty acids with perceived stress score or cortisol level in FF genotype carriers, but lower intake of PUFA was related to higher cortisol level (P=0.04) in Ff carriers. Significant interactions were observed between VDR FOKI polymorphism and intakes of eicosapentaenoic acid (EPA) (P Interaction=0.06), linoleic acid (P Interaction=0.06), and docosahexaenoic acid (DHA) (P Interaction=0.06) on serum cortisol, so that lower intake of EPA, linoleic acid, and DHA was associated with an increase in cortisol levels in individuals with ff genotype. Moreover, in carriers of ff genotype, lower intake of EPA was related to the elevated perceived stress score (P Interaction=0.06). Conclusion: FokI polymorphism interacts with omega-3 fatty acids (EPA, linoleic acid, and DHA) to increase cortisol level and with EPA to increase perceived stress score in nurses.
 
Full-Text [PDF 1032 kb]   (172 Downloads) |   |   Full-Text (HTML)  (162 Views)  
Type of article: orginal article | Subject: public specific
Received: 2022/12/9 | Published: 2024/02/21 | ePublished: 2024/02/21

References
1. Alizadeh S, Djafarian K, Alizadeh H, Mohseni R & Shab-Bidar S 2017. Common variants of vitamin D receptor gene polymorphisms and susceptibility to coronary artery disease: a systematic review and meta-analysis. Lifestyle genomics. 10 (1-2): 9-18.
2. Alizadeh S, et al. 2018. Vitamin D3 Induces Gene Expression of Ox-LDL Scavenger Receptors in Streptozotocin-Induced Diabetic Rat Aortas: New Insight into the Role of Vitamin D in Diabetic Atherosclerosis. Reports of biochemistry & molecular biology. 6 (2): 170.
3. Barbadoro P, et al. 2013. Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo‐controlled trial in abstinent alcoholics. Molecular nutrition & food research. 57 (6): 1110-1114.
4. Bernburg M, Groneberg DA & Mache S 2019. Mental Health Promotion Intervention for Nurses Working in German Psychiatric Hospital Departments: A Pilot Study. Issues in mental health nursing. 40 (8): 706-711.
5. Bhatia N, Kishore J, Anand T & Jiloha RC 2010. Occupational stress amongst nurses from two tertiary care hospitals in Delhi. Australasian medical journal 3(11): 731.
6. El Ansari W & Berg-Beckhoff G 2015. Nutritional correlates of perceived stress among university students in Egypt. International journal of environmental research and public health. 12 (11): 14164-14176.
7. Eyles DW, Smith S, Kinobe R, Hewison M & McGrath JJ 2005. Distribution of the vitamin D receptor and 1α-hydroxylase in human brain. Journal of chemical neuroanatomy. 29 (1): 21-30.
8. Fitzgerald JS, Orysiak J, Wilson PB, Mazur-Różycka J & Obminski Z 2018. Association between vitamin D status and testosterone and cortisol in ice hockey players. Biology of sport. 35 (3): 207.
9. George SA, Khan S, Briggs H & Abelson JL 2010. CRH-stimulated cortisol release and food intake in healthy, non-obese adults. Psychoneuroendocrinology. 35 (4): 607-612.
10. Gheshlagh R, et al. 2017. The prevalence of job stress among nurses in Iran: A meta-analysis study. Nursing and midwifery studies. 6 (4): 143-148.
11. Glocke M, et al. 2013. Impact of vitamin D receptor VDR rs2228570 polymorphism in oldest old. Kidney and blood pressure research. 37 (4-5): 311-322.
12. Guilliams TG & Edwards L 2010. Chronic stress and the HPA axis. Standard. 9 (2): 1-12.
13. Hamazaki T, Itomura M, Sawazaki S & Nagao Y 2000. Anti-stress effects of DHA. Biofactors. 13 (1-4): 41-45.
14. Harbron J, Van der Merwe L, Zaahl MG, Kotze MJ & Senekal M 2014. Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight/obese Caucasian adults. Nutrients. 6 (8): 3130-3152.
15. Higbee MR, Chilton JM, El-Saidi M, Duke G & Haas BK 2020. Nurses Consuming Energy Drinks Report Poorer Sleep and Higher Stress. Western journal of nursing research. 42 (1): 24-31.
16. Ji LL, et al. 2014. Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress. Molecular medicine reports. 9 (4): 1165-1170.
17. Junne F, et al. 2017. Determinants of perceived stress in individuals with obesity: exploring the relationship of potentially obesity-related factors and perceived stress. Obesity facts. 10 (2): 127-138.
18. Kalueff AV, Lou Y-R, Laaksi I & Tuohimaa P 2004. Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport. 15 (8): 1271-1274.
19. Keenan K, Hipwell AE, Bortner J, Hoffmann A & McAloon R 2014. Association between fatty acid supplementation and prenatal stress in African Americans: a randomized controlled trial. Obstetrics and gynecology. 124 (6): 1080.
20. Kim HS, et al. 2001. Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Cancer epidemiology and prevention biomarkers. 10 (8): 869-874.
21. Kuningas M, et al. 2009. VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiology of aging. 30 (3): 466-473.
22. Lange KW 2020. Omega-3 fatty acids and mental health. Global health journal. 4 (1): 18-30.
23. Layé S 2010. Polyunsaturated fatty acids, neuroinflammation and well being. Prostaglandins, leukotrienes and essential fatty acids. 82 (4-6): 295-303.
24. Maddahi NS, et al. 2020. Association between dietary energy density with mental health and sleep quality in women with overweight/obesity. BMC research notes. 13 (1): 1-6.
25. Maroufizadeh S, Zareiyan A & Sigari N 2014. Reliability and validity of Persian version of perceived stress scale (PSS-10) in adults with asthma. Archives of Iranian medicine. 17 (5): 0-0.
26. Miller AH, Maletic V & Raison CL 2009. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biological psychiatry. 65 (9): 732-741.
27. Rodriguez ACI, et al. 2015. Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: a systematic review. Psychoneuroendocrinology. 62: 301-318.
28. Rolf L, et al. 2018. Stress-axis regulation by vitamin D3 in multiple sclerosis. Frontiers in neurology. 9: 263.
29. Takeuchi T, Iwanaga M & Harada E 2003. Possible regulatory mechanism of DHA-induced anti-stress reaction in rats. Brain research. 964 (1): 136-143.
30. Taylor AM & Holscher HD 2020. A review of dietary and microbial connections to depression, anxiety, and stress. Nutritional neuroscience. 23 (3): 237-250.
31. Walvekar SS, Ambekar JG & Devaranavadagi BB 2015. Study on serum cortisol and perceived stress scale in the police constables. Journal of clinical and diagnostic research. 9 (2): BC10.
32. Wingenfeld K, et al. 2017. Stress reactivity and its effects on subsequent food intake in depressed and healthy women with and without adverse childhood experiences. Psychoneuroendocrinology. 80: 122-130.
33. Yalamanchili V & Gallagher JC 2012. Treatment with hormone therapy and calcitriol did not affect depression in elderly postmenopausal women: no interaction with estrogen and vitamin D receptor genotype polymorphisms. Menopause. 19 (6): 697.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 3.0 | Journal of Nutrition and Food Security

Designed & Developed by : Yektaweb