Sat, Nov 9, 2024
[Archive]
Volume 9, Issue 1 (Feb 2024)
JNFS 2024, 9(1): 173-188 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Derakhshandeh-Rishehri S, Rajabzadeh-Dehkordi M, Ghobadi S, Faghih S. The Effects of Conjugated Linoleic Acid Supplements on Biomarkers of Oxidative Stress in Human Studies: A Systematic Review and Meta-Analysis. JNFS 2024; 9 (1) :173-188
URL: http://jnfs.ssu.ac.ir/article-1-631-en.html
URL: http://jnfs.ssu.ac.ir/article-1-631-en.html
DONALD Study Center, Department of Nutritional Epidemiology, Institute of Nutrition and Food Science, University of Bonn, 44225 Dortmund, Germany
Abstract: (999 Views)
Oxidative stress is the leading cause of chronic disorders. The aim of the present study is to assess the effects of conjugated linoleic acid (CLA) supplements on oxidative stress biomarkers in adults. Methods: PubMed, Web of Science, Google Scholar, ProQuest, Scopus, and Embase were searched up to December 2020. All clinical trials that evaluated the effect of CLA on malondialdehyde (MDA), GSH-peroxidase (GPX), and 8-IsoprostanesF2α (8-iso-PGF2α) were included. Results: Twelve eligible studies were included in the meta-analysis. A significant increase was observed in 8-iso-PGF2α level (SMD=1.48 nmol/mmol of creatinine; 95% CI: 1.11 to 1.85) with low heterogeneity level (I2= 31.5%, and P=0.199). This effect was also significant in both subgroups of healthy and metabolic disorder individuals. Moreover, after Hartung-Knapp adjustment, the results remained significant. No significant changes were found in MDA (SMD=-0.34 µmol/l; 95% CI: -0.82 to 0.14) and GPX (SMD=0.31 U/gHb; 95% CI: -0.03 to 0.66) levels. However, after Hartung-Knapp adjustment, the results became significant for GPX level (SMD=0.31, 95% CI: 0.04 to 0.59). Conclusion: CLA supplementation could significantly increase some markers of oxidative stress such as 8-iso-PGF2α level and GPX level, without any significant effect on MDA level.
Type of article: review article |
Subject:
public specific
Received: 2022/05/14 | Published: 2024/02/21 | ePublished: 2024/02/21
Received: 2022/05/14 | Published: 2024/02/21 | ePublished: 2024/02/21
References
1. Anderson C, Milne GL, Sandler DP & Nichols HB 2016. Oxidative stress in relation to diet and physical activity among premenopausal women. British journal of nutrition. 116 (8): 1416-1424.
2. Aryaeian N, et al. 2009. The effect of conjugated linoleic acids, vitamin e and their combination on lipid peroxidation in active rheumatoid arthritis. Iranian journal of public health. 38 (2): 79-89.
3. Basu S 1998. Radioimmunosassay of 8-iso-prostaglandin F2α: an index for oxidative injury via free radical catalysed lipid peroxidation. Prostaglandins, leukotrienes and essential fatty acids. 58 (4): 319-325.
4. Basu S, Risérus U, Turpeinen A & Vessby B 2000a. Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clinical science. 99 (6): 511-516.
5. Basu S, Smedman A & Vessby B 2000b. Conjugated linoleic acid induces lipid peroxidation in humans. FEBS letters. 468 (1): 33-36.
6. Cornish SM, et al. 2009. Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training. International journal of sports medicine and exercise metabolism. 19 (1): 79-96.
7. Derakhshandeh-Rishehri SM, Rahbar AR & Ostovar A 2019. Effects of Conjugated Linoleic Acid Intake in the Form of Dietary Supplement or Enriched Food on C-Reactive Protein and Lipoprotein (a) Levels in Humans: A Literature Review and Meta-Analysis. Iranian journal of medical sciences. 44 (5): 359-373.
8. Diaz ML, Watkins BA, Li Y, Anderson RA & Campbell WW 2008. Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight women. Journal of nutritional biochemistry. 19 (1): 61-68.
9. Ebrahimi-Mameghani M, et al. 2016. Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial. Croatian medical journal. 57 (4): 331-342.
10. Eftekhari MH, Aliasghari F, Babaei-Beigi MA & Hasanzadeh J 2013. Effect of conjugated linoleic acid and omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in atherosclerotic patients. ARYA atherosclerosis. 9 (6): 311.
11. Follmann D, Elliott P, Suh I & Cutler J 1992. Variance imputation for overviews of clinical trials with continuous response. Journal of clinical epidemiology. 45 (7): 769-773.
12. Ghaedi E, Kord-Varkaneh H, Mohammadi H, Askarpour M & Miraghajani M 2020. Phytosterol Supplementation Could Improve Atherogenic and Anti-Atherogenic Apolipoproteins: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Journal of American collage of nutrition. 39 (1): 82-92.
13. Ghaedi E, et al. 2019. Possible anti‐obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose–response meta‐analysis of randomized controlled trials. Phytotherapy research. 33 (5): 1246-1257.
14. Guyatt G, et al. 2011a. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. Journal of clinical epidemiology. 64 (4): 383-394.
15. Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P & Knottnerus A 2011b. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. Journal of clinical epidemiology. 64 (4): 380-382.
16. Hadi A, Pourmasoumi M, Ghaedi E & Sahebkar A 2019. The effect of Curcumin/Turmeric on blood pressure modulation: A systematic review and meta-analysis. Pharmacological research. 150: 104505.
17. Higgins JP, et al. 2019. Cochrane handbook for systematic reviews of interventions. John Wiley & Sons.
18. Iannone A, et al. 2009. Impairment of 8-iso-PGF2ALPHA isoprostane metabolism by dietary conjugated linoleic acid (CLA). Prostaglandins, leukotrienes and essential fatty acids. 80 (5-6): 279-287.
19. IntHout J, Ioannidis JP & Borm GF 2014. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC medical research methodology. 14: 25.
20. Kavanaugh CJ, Liu K-L & Belury MA 1999. Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. Nutrition and cancer. 33 (2): 132-138.
21. Kim J, Paik HD, Shin MJ & Park E 2012. Eight weeks of conjugated linoleic acid supplementation has no effect on antioxidant status in healthy overweight/obese Korean individuals. European journal of nutrition. 51 (2): 135-141.
22. Knight JA 2000. Free radicals, antioxidants, and the immune system. Annals of clinical & laboratory science. 30 (2): 145-158.
23. Kord-Varkaneh H, Ghaedi E, Nazary-Vanani A, Mohammadi H & Shab-Bidar S 2018. Does cocoa/dark chocolate supplementation have favorable effect on body weight, body mass index and waist circumference? A systematic review, meta-analysis and dose-response of randomized clinical trials. Critical reviews in food science and nutrition. 59 (15): 2349-2362.
24. Kuhnt K, Wagner A, Kraft J, Basu S & Jahreis G 2006. Dietary supplementation with 11trans- and 12trans-18:1 and oxidative stress in humans. American clinical nutrition. 84 (5): 981-988.
25. Laso N, et al. 2007. Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components. British journal nutrition. 98 (4): 860-867.
26. Marrocco I, Altieri F & Peluso I 2017. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxidative medicine and cellular longevity. 2017: 6501046.
27. Mataix, Ochoa & Quiles 2006. Olive oil and mitochondrial oxidative stress. International journal for vitamin and nutrition research. 76 (4): 178-183.
28. Matin S, Nemati A, Ghobadi H, Alipanah-Moghadam R & Rezagholizadeh L 2018. The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD. International journal of chronic obstructive pulmonary disease. 13: 1449-1454.
29. Mazon JN, de Mello AH, Ferreira GK & Rezin GT 2017. The impact of obesity on neurodegenerative diseases. Life sciences. 182: 22-28.
30. Meagher EA & FitzGerald GA 2000. Indices of lipid peroxidation in vivo: strengths and limitations. Free radical biology and medicine. 28 (12): 1745-1750.
31. Mirzaii S, Mansourian M, Derakhshandeh-Rishehri SM, Kelishadi R & Heidari-Beni M 2016. Association of conjugated linoleic acid consumption and liver enzymes in human studies: A systematic review and meta-analysis of randomized controlled clinical trials. Nutrition. 32 (2): 166-173.
32. Morrow JD & Roberts LJ 1997. The isoprostanes: unique bioactive products of lipid peroxidation. Progress in lipid research. 36 (1): 1-21.
33. Muñoz A & Costa M 2013. Nutritionally mediated oxidative stress and inflammation. Oxidative medicine and cellular longevity. 2013: 1-11.
34. Ormezzano O, et al. 2005. F2-Isoprostane level is associated with the angiotensin II type 1 receptor-153A/G gene polymorphism. Free radical biology and medicine. 38 (5): 583-588.
35. Pfeuffer M, et al. 2011. CLA does not impair endothelial function and decreases body weight as compared with safflower oil in overweight and obese male subjects. Journal of American collage nutrition. 30 (1): 19-28.
36. Risérus U, Arner P, Brismar K & Vessby B 2002a. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes care. 25 (9): 1516-1521.
37. Risérus U, et al. 2002b. Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation. 106 (15): 1925-1929.
38. Risérus U, Vessby B, Arner P & Zethelius B 2004a. Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia. 47 (6): 1016-1019.
39. Risérus U, Vessby B, Arnlöv J & Basu S 2004b. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. American journal clinical nutrition. 80 (2): 279-283.
40. Schünemann HJ, et al. 2008. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. British medical journal. 336 (7653): 1106-1110.
41. Shadman Z, Taleban FA, Saadat N & Hedayati M 2013. Effect of conjugated linoleic acid and vitamin E on glycemic control, body composition, and inflammatory markers in overweight type2 diabetics. Journal of diabetes & metabolic disorders 12 (1): 42.
42. Silveira M-B, Carraro R, Monereo S & Tébar J 2007. Conjugated linoleic acid (CLA) and obesity. Public health nutrition. 10 (10A): 1181-1186.
43. Smedman A, Vessby B & Basu S 2004. Isomer-specific effects of conjugated linoleic acid on lipid peroxidation in humans: regulation by alpha-tocopherol and cyclo-oxygenase-2 inhibitor. Clinical science. 106 (1): 67-73.
45. Tan BL & Norhaizan ME 2019. Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. Nutrients. 11 (11).
46. Tan BL, Norhaizan ME & Liew WP 2018. Nutrients and Oxidative Stress: Friend or Foe? Oxidative medicine and cellular longevity. 2018: 9719584.
47. Tarnopolsky M, et al. 2007. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS One. 2 (10): e991.
48. Tomey KM, et al. 2007. Dietary fat subgroups, zinc, and vegetable components are related to urine F2a-isoprostane concentration, a measure of oxidative stress, in midlife women. Journal of nutrition. 137 (11): 2412-2419.
49. Turpeinen AM, Ylönen N, von Willebrand E, Basu S & Aro A 2008. Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy. British journal of nutrition. 100 (1): 112-119.
50. Wang L, et al. 2017. Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics. Journal of experimental & clinical cancer research. 36 (1): 47.
51. Whigham LD, Watras AC & Schoeller DA 2007. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. American journal of clinical nutrition. 85 (5): 1203-1211.
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
