Volume 8, Issue 1 (Feb 2023)                   JNFS 2023, 8(1): 108-113 | Back to browse issues page

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Mirzaii-Dizgah M, Mirzaii-Dizgah M, Mirzaii-Dizgah I, Koshkzari R. The Association between Saliva and Serum Vitamin D with Knee Osteoarthritis. JNFS 2023; 8 (1) :108-113
URL: http://jnfs.ssu.ac.ir/article-1-475-en.html
Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
Abstract:   (1152 Views)
Background: The incidence of osteoarthritis (OA) is high in patients suffering from 25-hydroxyvitamin D3 (25(OH)D) deficiency. The goal of this study is to examine the association between saliva and serum 25(OH)D and knee OA. Methods: Serum and saliva 25(OH)D levels of 30 patients with knee OA and 30 matched healthy people in a control group were measured by ELISA. Knee pain was assessed by Western Ontario and McMaster Universities Arthritis Index (WOMAC). Data were analyzed through student’s t-test, Pearson correlation test and receiver operating characteristic (ROC). Results: The mean serum and saliva 25(OH)D levels were lower in knee OA group than the healthy group. WOMAC negatively correlated with serum (r = -0.37; P = 0.02) and with unstimulated
r = -0.30; P = 0.04) saliva 25(OH)D. The unstimulated saliva 25(OH)D cutoff value was 27.8 pg/m1 regarding the diagnosis of knee OA. Conclusion: Serum 25(OH)D levels were positively associated with saliva 25(OH)D, and 25(OH)D level in saliva, as in serum, was low in knee OA.

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Type of article: orginal article | Subject: public specific
Received: 2021/09/9 | Published: 2023/02/21 | ePublished: 2023/02/21

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