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Teymourian H, Ashrafi F, Behnaz F, Azizi Faresani H, Rezaee-Tazangi F R, Sotoudeh N, et al . Effects of Daily Intake of Plant and Animal Oils on the Incidence of Depression in Adult Mice. JNFS 2021; 6 (4) :289-295
URL: http://jnfs.ssu.ac.ir/article-1-366-fa.html

Background: Depression is a complicated disturbance affected by a collection of biological and environmental factors. The first aim of psychiatric studies is to recognize biological markers that could be utilized to predict improvement and increase reactions to antidepressant treatments. Diet affects different aspects of health, including depression. The aim of study was to determine antidepressant-like effects of some consumable oils, the effects of oils on depression were compared. Methods: Thirty-two male and female mice (Mus musculus (BALB/c)) weighing 25- 35 g were randomly divided into 8 groups (4 mice in each group, 2 male and 2 female, A: Laden sunflower liquid oil, B: 50% vegetable oil + 50% olive oil, C: Kermanshah Rojin animal oil, D: Spring frying oil, E: Distilled water, F: BAHAR solid vegetable oil, G: Olive oil, H: 50% Kermanshah animal oil + 50% of olive oil). In different groups, 30 g of vegetable or animal oil was gavaged every day at 1:00 pm. Five types of vegetable and animal oils among the high consumption oils in the market were selected, including spring frying oil (used for several times in 305˚f, usually used in eastern Asia countries), Laden sunflower liquid oil, olive oil, Kermanshah Rojin animal oil, and BAHAR solid vegetable oil. After 6 weeks of using the oils diet, the forced swim test was utilized as a test of depression like behavior. Results: There was a significant difference between all groups (P < 0.0001). Based on the results, the latency time of immobility in group A significantly decreased in comparison with groups C (P ˂ 0.02), D (P ˂ 0.003), and G (P < 0.001). However, it increased in groups B and C compared to group H (P ˂ 0.02). Also, this parameter in group D increased significantly compared to groups E (P < 0.01), F (P < 0.05), and H (P < 0.002). Conclusion: The results indicated that olive oil had a preventive effect against forced swimming-induced depression-like symptoms.