Volume 1, Issue 1 (November 2016)                   JNFS 2016, 1(1): 9-15 | Back to browse issues page

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Karandish M, Hosseinpour M, Rashidi H, Latifi S M, Moravej Aleali A. Comparison of Components of Metabolic Syndrome among Metabolically Obese Normal Weight, Metabolically Benign Normal Weight, and Metabolically Abnormal Obese Iranian Children and Adolescents in Ahvaz. JNFS 2016; 1 (1) :9-15
URL: http://jnfs.ssu.ac.ir/article-1-27-en.html
Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (4588 Views)

Background: Metabolically obese normal-weight (MONW) children and adolescents are characterized by body mass index (BMI) lower than +1SD with metabolic disorders such as hyperglycemia, hypertriglyceridemia, and/or hypertension. This study wants to determineprevalence of MONW, metabolically benign normal weight (MBNW), metabolically abnormality obese (MAO) and comparethe components of metabolic syndrome (MetS) in some Iranian normal-weight children and adolescents in Ahvaz, Iran. Methods: This cross-sectional study was conducted on 1124 boys and 1128 girls, aged 10–18 y, Ahvaz, Khuzestan.Participants were selected from 6 health centers in Ahvaz by a multistage cluster random sampling method. The Mets was defined according to the modified Adult Treatment Panel III (ATP III). Anthropometric measurements and blood pressure were measured according to standard protocols. Fasting blood samples were collected for biochemical assessment. Results: MetS prevalence in normal weight group was 5.4% and 1.45% in  boys and girls, respectively (P = 0.001) showing a significant difference. Triglyceride abnormality percentages (MBNW = 23.9%, MAO = 88.8%, MONW = 91%) and high density lipoprotein (MBNW = 19.2%, MAO = 73.8% and MONW = 67.2%) were higher than other MetS components in these groups. Conclusions: Since BMI in children and adolescents with metabolically obese-normal weight is normal‚ the continuous measurements and treatment of MetS components especially in boys are important from public health view. The components mean of MetS was higher in MONW and MAO individuals compared with MBNW.

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Received: 2016/04/30 | Published: 2016/09/4 | ePublished: 2016/09/4

References
1. Adams MR, Forsyth CJ, Jessup W, Robinson J & Celermajer DS 1995. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. Journal of the American College of Cardiology.26(4): 1054-1061.
2. Adams MR, et al. 1997. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis.129(2): 261-269.
3. Adler AI, et al. 2000. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. Bmj.321(7258): 412-419.
4. Amezcua J, Dusting G, Palmer R & Moncada S 1988. Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator. British journal of pharmacology.95(3): 830-834.
5. Ast J, et al. 2011. Supplementation with L-arginine does not influence arterial blood pressure in healthy people: a randomized, double blind, trial. Eur Rev Med Pharmacol Sci.15(12): 1375-1384.
6. Azimi-Nezhad M, et al. 2008. Prevalence of type 2 diabetes mellitus in Iran and its relationship with gender, urbanisation, education, marital status and occupation. Singapore medical Journal.49(7): 571.
7. Bode-Boger S, et al. 1994. L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clinical science.87(3): 303-310.
8. Bode-Böger SM, et al. 1996. l-Arginine Induces Nitric Oxide–Dependent Vasodilation in Patients With Critical Limb Ischemia A Randomized, Controlled Study. Circulation.93(1): 85-90.
9. Böger RH, et al. 1997. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits comparison with lovastatin. Circulation.96(4): 1282-1290.
10. Burke JP, et al. 1999. Rapid rise in the incidence of type 2 diabetes from 1987 to 1996: results from the San Antonio Heart Study. Archives of Internal Medicine.159(13): 1450-1456.
11. Chan N & Vallance P 2002. The L-arginine-nitric oxide pathway. In An Introduction to Vascular Biology: From Basic Science to Clinical Practice (ed. H. Beverley J, P. Lucilla, S. Michael and H. Alison W), p. 216. University of Cambridge: United kingdom.
12. Chen Y & Reaven G 1997. Insulin resistance and atherosclerosis. Diabetes Reviews.5(4): 331-342.
13. Chin-Dusting JP, et al. 1996a. Effects of in vivo and in vitro L-arginine supplementation on healthy human vessels. Journal of cardiovascular pharmacology.28(1): 158-166.
14. Chin-Dusting JP, et al. 1996b. Dietary supplementation with L-arginine fails to restore endothelial function in forearm resistance arteries of patients with severe heart failure. Journal of the American College of Cardiology.27(5): 1207-1213.
15. Cocks T & Angus J 1983. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature.305, : 627-630.
16. Delavari AR MHA, Norozinejad A, Yarahmadi SH 2004. Country programme of prevention and control of diabetes. Seda Publication: Tehran, Iran.
17. Esteghamati A, et al. 2008. prevalence of diabetes and impaired fasting glucose in the adult population of Iran national survey of risk factors for non-communicable diseases of Iran. Diabetes care.31(1): 96-98.
18. Evans RW, Fernstrom JD, Thompson J, Morris SM & Kuller LH 2004. Biochemical responses of healthy subjects during dietary supplementation with L-arginine. The Journal of nutritional biochemistry.15(9): 534-539.
19. Facchinetti F, et al. 2007. L-arginine supplementation in patients with gestational hypertension: a pilot study. Hypertension in pregnancy.26(1): 121-130.
20. Garthwaite J & Boulton C 1995. Nitric oxide signaling in the central nervous system. Annual review of physiology.57(1): 683-706.
21. Garthwaite J, Charles SL & Chess-Williams R 1988. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain.
22. Giugliano D, et al. 1997a. Vascular effects of acute hyperglycemia in humans are reversed by L-arginine evidence for reduced availability of nitric oxide during hyperglycemia. Circulation.95(7): 1783-1790.
23. Giugliano D, et al. 1997b. L-arginine for testing endothelium-dependent vascular functions in health and disease. The American journal of physiology.273(3 Pt 1): E606-612.
24. Herman W, Konzelman Jr J & Prisant L 2004. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. New national guidelines on hypertension: a summary for dentistry. J Am Dent Assoc.135(5): 576-584.
25. Huynh NT & Tayek JA 2002. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. Journal of the American College of Nutrition.21(5): 422-427.
26. Iyengar R, Stuehr DJ & Marletta MA 1987. Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proceedings of the National Academy of Sciences.84(18): 6369-6373.
27. Katusic Z, Shepherd J & Vanhoutte P 1984. Vasopressin causes endothelium-dependent relaxations of the canine basilar artery. Circulation research.55(5): 575-579.
28. Kelly BS, et al. 2001. Oral arginine improves blood pressure in renal transplant and hemodialysis patients. Journal of Parenteral and Enteral Nutrition.25(4): 194-202.
29. Lechin F, et al. 2006. The effects of oral arginine on neuroautonomic parameters in healthy subjects. Journal of Applied Research in Clinical and Experimental Therapeutics.6(3): 201.
30. Lerman A, Burnett JC, Higano ST, McKinley LJ & Holmes DR 1998. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation. 97(21): 2123-2128.
31. Lucotti P, et al. 2006. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. American Journal of Physiology-Endocrinology and Metabolism.291(5): E906-E912.
32. Luiking YC, Engelen MP & Deutz NE 2010. Regulation of nitric oxide production in health and disease. Current opinion in clinical nutrition and metabolic care.13(1): 97.
33. Marietta M, et al. 1997. L-arginine infusion decreases platelet aggregation through an intraplatelet nitric oxide release. Thrombosis research.88(2): 229-235.
34. Martina V, et al. 2008. Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes. Diabetes Care.31(5): 940-944.
35. Miller AL 2006. The effects of sustained-release-L-arginine formulation on blood pressure and vascular compliance in 29 healthy individuals. Alternative medicine review: a journal of clinical therapeutic.11(1): 23-29.
36. Mimran A, Ribstein J & DuCailar G 1995. Contrasting effect of antihypertensive treatment on the renal response to L-arginine. Hypertension.26(6): 937-941.
37. Mirfattahi M, et al. 2012. Effect of L-arginine Supplementation on Blood Pressure in overweight Patients with prediabetes. Iranian Journal of Diabetes and Lipid Disorders.11(4): 393-399. (In Farsi)
38. Palmer RM, Ashton D & Moncada S 1988. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature.333(6174): 664-666.
39. Palmer RM, Ferrige A & Moncada S 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature.327: 524-526.
40. Radomski M, Palmer R & Moncada S 1987. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. The Lancet.330(8567): 1057-1058.
41. Rajapakse NW & Mattson DL 2009. Role of L‐arginine in nitric oxide production in health and hypertension. Clinical and Experimental Pharmacology and Physiology.36(3): 249-255.
42. Rector TS, et al. 1996. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation.93(12): 2135-2141.
43. Rees DD, Palmer RM, Hodson HF & Moncada S 1989. A specific inhibitor of nitric oxide formation from l‐arginine attenuates endothelium‐dependent relaxation. British journal of pharmacology.96(2): 418-424.
44. Rytlewski K, Olszanecki R, Korbut R & Zdebski Z 2005. Effects of prolonged oral supplementation with l‐arginine on blood pressure and nitric oxide synthesis in preeclampsia. European journal of clinical investigation.35(1): 32-37.
45. Steinberg H, Brechtel G, Johnson A, Fineberg N & Baron A 1994. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. Journal of clinical investigation.94(3): 1172.
46. Unit ES 2005. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet.366(9493): 1267-1278.
47. Vincent SR 1994. Nitric oxide: a radical neurotransmitter in the central nervous system. Progress in neurobiology.42(1): 129-160.
48. Visek WJ 1986. Arginine needs, physiological state and usual diets. A reevaluation. The Journal of nutrition.116(1): 36-46.
49. West SG, Likos-Krick A, Brown P & Mariotti F 2005. Oral L-arginine improves hemodynamic responses to stress and reduces plasma homocysteine in hypercholesterolemic men. The Journal of nutrition.135(2): 212-217.
50. Wu G & MORRIS JS 1998. Arginine metabolism: nitric oxide and beyond. Biochem. J.336: 1-17.
51. Zhang X, et al. 2001. L-arginine supplementation in young renal allograft recipients with chronic transplant dysfunction. Clinical nephrology.55(6): 453-459.

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