Background: The purpose of this study was to investigate the effect of an eight-week combined exercise training program with sweet almond supplementation on plasma levels of leptin and orexin in overweight women. Methods: This research was a quasi-experimental study. The statistical population consisted of 60 overweight women with a body mass index (BMI) of 25-30 kg/m2 who were randomly divided into four groups of training, training-sweet almond supplement, supplement, and control. The participants participated in three training sessions weekly and consumed sweet almond supplementation for eight consecutive weeks. The participants' blood samples were taken 24 hours before the first session and after the last session, in a 12-hour fasting state. Liptin concentrations were measured using Pishtaz Teb Inc. kits. Orexin levels were determined through enzymatic method using the Virro Inc. kit. A two-way repeated measures ANOVA was conducted to analyze the inter- and intra-group variance. The overall alpha significance level was set at P ≤ 0.05 for all the statistical analyses. Results: Eight weeks of combined exercise training with sweet almond supplementation Showed a significant reduces in serum level leptin concentration and increased the plasma orexin levels. Conclusion: According to the results of the present study It can be used from combined training and sweet almonds to reduce appetite and lose weight in overweight women.