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JNFS 2025, 10(1): 15-22 |
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Narmcheshm S, Toorang F, Sasanfar B, Hadji M, Dorosty Motlagh A, Zendehdel K. Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study. JNFS 2025; 10 (1) :15-22
URL: http://jnfs.ssu.ac.ir/article-1-1071-en.html
URL: http://jnfs.ssu.ac.ir/article-1-1071-en.html
Saba Narmcheshm 
, Fatemeh Toorang , Bahareh Sasanfar , Maryam Hadji , Ahmadreza Dorosty Motlagh , Kazem Zendehdel *
, Fatemeh Toorang , Bahareh Sasanfar , Maryam Hadji , Ahmadreza Dorosty Motlagh , Kazem Zendehdel *
Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (395 Views)
Background: Gastric cancer (GC) is the most common cancer among Iranian men. A diet rich in antioxidant compounds has been offered as an appropriate strategy for reducing the risk of GC. This study aimed to determine the possible association between dietary total antioxidant capacity (dTAC) and the Iranian population's GC risk. Methods: In total, 178 newly diagnosed GC patients and 238 healthy controls were recruited for this hospital-based case-control study. Dietary intakes were collected using a validated 146-item diet history questionnaire (DHQ), and dTAC was analyzed using Ferric reducing antioxidant potential (FRAP) assay. Results: The mean value of dTAC was 10.42±5.42 for cases and 11.42±5.86 for controls. Black tea, fruits, and cereals consumption were the main contributors to dTAC in both groups. DTAC was associated with a reduction in the risk of GC (OR 0.54; 95%CI: 0.31–0.92) (second vs. lowest tertile). This association did not change after adjustment for body mass index, education, energy intake, smoking, and Helicobacter pylori infection (0.55; 95% CI: 0.31-0.99). There was no significant association between fruits, vegetables, nuts, and legumes TAC with GC. Conclusion: The whole intake of dTAC from different food sources was not high in the population; however, this amount showed a preventive effect against GC.
Type of article: orginal article |
Subject:
public specific
Received: 2024/05/27 | Published: 2025/02/4 | ePublished: 2025/02/4
Received: 2024/05/27 | Published: 2025/02/4 | ePublished: 2025/02/4
References
1. Azar M & E. S 1980. Food Composition Table of Iran. National Nutrition and Food Research Institute. Tehran: Shaheed Beheshti University.
2. Benzie IFF & Strain JJ 1996. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical biochemistry. 239 (1): 70-76.
3. Carlsen MH, et al. 2010. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutrition journal. 9 (1): 3.
4. Chen R-C, et al. 2002. Effect of isoverbascoside, a phenylpropanoid glycoside antioxidant, on proliferation and differentiation of human gastric cancer cell. Acta pharmacologica cinica. 23 (11): 997-1001.
5. Deandrea S, et al. 2010. Is temperature an effect modifier of the association between green tea intake and gastric cancer risk? European journal of cancer prevention. 19 (1): 18-22.
6. Ekström AM, Held M, Hansson L-E, Engstrand L & Nyrén O 2001. Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology. 121 (4): 784-791.
7. Farmanfarma KK, Mahdavifar N, Hassanipour S & Salehiniya H 2020. Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review. Clinical and experimental gastroenterology. 13: 511.
8. Foksinski M, et al. 2007. Effects of basal level of antioxidants on oxidative DNA damage in humans. European journal of nutrition. 46 (3): 174.
9. Halliwell B, Zhao K & Whiteman M 2000. The gastrointestinal tract: a major site of antioxidant action? Free radical research. 33 (6): 819-830.
10. Helicobacter Cancer Collaborative Group 2001. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 49 (3): 347-353.
11. International Agency for Research on Cancer 2020a. Stomach Fact Sheet.
12. International Agency for Research on Cancer 2020b. World Cancer Fact Sheets.
13. McLean MH & El-Omar EM 2014. Genetics of gastric cancer. Nature reviews gastroenterology & hepatology. 11 (11): 664-674.
14. Metere A & Giacomelli L 2017. Absorption, metabolism and protective role of fruits and vegetables polyphenols against gastric cancer. European review for medical and pharmacological sciences. 21: 5850-5858.
15. Nascimento-Souza MA, Paiva PG, Martino HSD & Ribeiro AQ 2018. Dietary total antioxidant capacity as a tool in health outcomes in middle-aged and older adults: a systematic review. Critical reviews in food science and nutrition. 58 (6): 905-912.
16. Praud D, et al. 2015. Non-enzymatic antioxidant capacity and risk of gastric cancer. Cancer epidemiology. 39 (3): 340-345.
17. Rawla P & Barsouk A 2019. Epidemiology of gastric cancer: global trends, risk factors and prevention. Przeglad gastroenterologiczny. 14 (1): 26-38.
18. Roshandel G, et al. 2021. Cancer in Iran 2008 to 2025: Recent incidence trends and short‐term predictions of the future burden. International journal of cancer. 149 (3): 594-605.
19. Serafini M, Bellocco R, Wolk A & Ekström AM 2002. Total antioxidant potential of fruit and vegetables and risk of gastric cancer. Gastroenterology. 123 (4): 985-991.
20. Serafini M, et al. 2012. Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. International journal of cancer. 131 (4): E544-E554.
21. Toorang F, et al. 2019. Validation of Diet History Questionnaire in Assessing Energy and Nutrient Intakes of Iranian Population. Iranian journal of public health. 48 (6): 1074-1081.
22. United States Department of Agriculture hfnug 2018. FoodData Central.
23. Wang Y, Duan H & Yang H 2015. A case-control study of stomach cancer in relation to Camellia sinensis in China. Surgical oncology. 24 (2): 67-70.
24. Wikipedia 2016. List of countries by tea consumption per capita.
25. Willett WC, Howe GR & Kushi LH 1997. Adjustment for total energy intake in epidemiologic studies. American journal of clinical nutrition. 65 (4): 1220S-1228S.
26. Yang Y, et al. 2019. The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression. Oxidative medicine and cellular longevity. 2019 (1): 3643715.
27. Zamani B, Daneshzad E & Azadbakht L 2019. Dietary total antioxidant capacity and risk of gastrointestinal cancers: a systematic review and meta-analysis of observational studies. Archives of Iranian medicine. 22 (6): 328-335.
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