دوره 8، شماره 4 - ( 8-1402 )
جلد 8 شماره 4 صفحات 576-565 |
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Sadeghi Nodoushan F, Hakimian F, Haghiralsadat B F, Taghiyar S. The Effect of Superparamagnetic Fe3O4 Nanoparticles Combined with Quercetin on Breast Cancer Cell Line (MCF-7). JNFS 2023; 8 (4) :565-576
URL: http://jnfs.ssu.ac.ir/article-1-893-fa.html
URL: http://jnfs.ssu.ac.ir/article-1-893-fa.html
The Effect of Superparamagnetic Fe3O4 Nanoparticles Combined with Quercetin on Breast Cancer Cell Line (MCF-7). Journal of Nutrition and Food Security. 1402; 8 (4) :565-576
چکیده: (532 مشاهده)
Background: Magnetic nanoparticles attract increasing interest due to their use in cancer therapy and as drug carriers for several other diseases. The present study investigates the physiochemical properties of quercetin-conjugated superparamagnetic Fe3O4 nanoparticles and their effects on breast cancer cell line MCF-7. Methods: A simple precipitation method was used to prepare the Poly Ethylene Imine (PEI)-coated Fe3O4 nanoparticles; they were then conjugated with flavonoid-compound quercetin on the surface via carboxylic/amine group using nanoprecipitation method. Then, the physical and chemical parameters were calculated using Zeta-sizer, scanning electron microscopy (SEM), and extract release patterns at 37 and 42 0C. Finally, the toxicity level of this quercetin- conjugated nanosystem on the MCF-7 cells was investigated by MTT assay. Results: The results showed that the prepared nanosystem attained about 74% of quercetin inclusion, 91.2 nm size, 65.1 mV zeta potential, spherical morphology and a controlled release. Compared to Fe3O4 nanoparticles and pure quercetin, MTT and microscopy analysis revealed that quercetin-conjugated Fe3O4 nanoparticles induced considerable cytotoxicity, and morphology changes against MCF7 cells. Conclusion: Quercetin-conjugated Fe3O4 nanoparticles have appropriate physiochemical properties; they can be a suitable carrier for drug delivery and a promising therapy for candidates.
Corresponding Author:Bibi Fatemeh Haghiralsadat
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Corresponding Author:Bibi Fatemeh Haghiralsadat
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دریافت: 1402/2/23 | انتشار: 1402/8/29 | انتشار الکترونیک: 1402/8/29
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