Volume 9, Issue 1 (Feb 2024)                   JNFS 2024, 9(1): 69-80 | Back to browse issues page


XML Print


Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (516 Views)
Vitamin D deficiency is a worldwide condition, which has been linked to a variety of health-related issues. Vitamin D can be beneficial to cardiovascular patients and those suffering from depression and anxiety, based on Survey of Ultraviolet Intake by Nutritional Approach (SUVINA study), ,showing the potential effects of vitamin D-fortified dairy products on anxiety, depression, and stress in subjects with cardiovascular disease (CVD) risk factors. Methods: It was a quadruple-blind randomized controlled trial. Individuals were randomly allocated to one of four groups: fortified low-fat milk (FM), non-fortified low-fat milk (NFM), fortified low-fat yogurt (FY), and non-fortified low-fat yogurt (NFY). FM and FY groups were fortified with 1500 IU nano-encapsulated vitamin D3. Anthropometric parameters as well as depression, anxiety, and stress scores were measured at baseline and after a ten-week trial in Mashhad, Iran. Results: Totally, 289 participants (143 men, 146 women) with a mean age of 41.86±7.81years were enrolled in the study. There was no statistical difference between the scores of depression, anxiety, and stress in participants with and without CVD risk factors (P>0.05).  No statistical difference was found in the subgroup analysis based on milk and yogurt consumption. Conclusions: Fortified low-fat milk containing 1,500 IU of vitamin D has no impact on improving depression, anxiety, and stress during ten weeks. However, further studies with higher vitamin D doses for a longer duration are recommended.
 
Full-Text [PDF 624 kb]   (91 Downloads) |   |   Full-Text (HTML)  (79 Views)  
Type of article: orginal article | Subject: public specific
Received: 2022/12/8 | Published: 2024/02/21 | ePublished: 2024/02/21

References
1. Alavi NM, Khademalhoseini S, Vakili Z & Assarian F 2019. Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial. Clinical nutrition. 38 (5): 2065-2070.
2. Alberti KGMM, Zimmet P & Shaw J 2006. Metabolic syndrome—a new world‐wide definition. A consensus statement from the international diabetes federation. Diabetic medicine. 23 (5): 469-480.
3. Amini S, Jafarirad S & Amani R 2019. Postpartum depression and vitamin D: A systematic review. Critical reviews in food science and nutrition. 59 (9): 1514-1520.
4. Amiri Z, et al. 2021. Factors determining the serum 25‐hydroxyvitamin D response to vitamin D supplementation: Data mining approach. BioFactors. 47 (5): 828-836.
5. Anglin RES, Samaan Z, Walter SD & McDonald SD 2013. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Journal of mental science. 202: 100-107.
6. Asadi Z, et al. 2019. Association Between dietary patterns and the risk of metabolic syndrome among Iranian population: A cross-sectional study. Diabetes & metabolic syndrome: Clinical research & reviews. 13 (1): 858-865.
7. Baecke JA, Burema J & Frijters JE 1982. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. American journal of clinical nutrition. 36 (5): 936-942.
8. Bayani AA 2010. Reliability and preliminary evidence of validity of a Farsi version of the depression anxiety stress scales. Perceptual and motor skills. 111 (1): 107-114.
9. Bertone-Johnson ER, et al. 2012. Vitamin D supplementation and depression in the women’s health initiative calcium and vitamin D trial. American journal of epidemiology. 176 (1): 1-13.
10. Bicikova M, et al. 2015. Vitamin D in anxiety and affective disorders. Physiological research. 64: S101.
11. Casseb GA, Kaster MP & Rodrigues ALS 2019. Potential role of vitamin D for the management of depression and anxiety. CNS drugs. 33 (7): 619-637.
12. Cheng YC, Huang YC & Huang WL 2020. The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis. Depression and anxiety. 37 (6): 549-564.
13. Cohen BE, Edmondson D & Kronish IM 2015. State of the art review: depression, stress, anxiety, and cardiovascular disease. American journal of hypertension. 28 (11): 1295-1302.
14. Cuomo A, et al. 2019. Prevalence and correlates of vitamin D deficiency in a sample of 290 inpatients with mental illness. Frontiers in psychiatry. 10: 167.
15. Darroudi S, et al. 2019. Oxidative stress and inflammation, two features associated with a high percentage body fat, and that may lead to diabetes mellitus and metabolic syndrome. Biofactors. 45 (1): 35-42.
16. Dean AJ, et al. 2011. Effects of vitamin D supplementation on cognitive and emotional functioning in young adults–a randomised controlled trial. PloS one. 6 (11): e25966.
17. Drozdenko G, Scheel T, Heine G, Baumgrass R & Worm M 2014. Impaired T cell activation and cytokine production by calcitriol‐primed human B cells. Clinical & experimental immunology. 178 (2): 364-372.
18. Ersoy N & Ersoy G Vitamin D deficiency and Depression: What Can We Do? Hacettepe Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. 4 (3): 1-14.
19. Etemad Z & Esmailnasab N 2012. The relationship between the level of physical activity and some risk factors of coronary heart disease in the university students. Scientific Journal of Kurdistan University of Medical Sciences. 17 (1).
20. Ganji V, Milone C, Cody MM, McCarty F & Wang YT 2010. Serum vitamin D concentrations are related to depression in young adult US population: the Third National Health and Nutrition Examination Survey. International archives of medicine. 3 (1): 1-8.
21. Gowda U, Mutowo MP, Smith BJ, Wluka AE & Renzaho AM 2015. Vitamin D supplementation to reduce depression in adults: meta-analysis of randomized controlled trials. Nutrition. 31 (3): 421-429.
22. Gutch M, Kumar S, Razi SM, Gupta KK & Gupta A 2015. Assessment of insulin sensitivity/resistance. Indian journal of endocrinology and metabolism. 19 (1): 160.
23. Högberg G, et al. 2012. Depressed adolescents in a case‐series were low in vitamin D and depression was ameliorated by vitamin D supplementation. Acta Paediatrica. 101 (7): 779-783.
24. Holick MF, et al. 2011. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Journal of clinical endocrinology & metabolism. 96 (7): 1911-1930.
25. Hossein-nezhad A & Holick MF 2013. Vitamin D for health: a global perspective. Mayo Clinic Proceedings. 88 (7): 720-755.
26. Jafarifar Z, et al. 2022. Preparation and characterization of nanostructured lipid carrier (NLC) and nanoemulsion containing vitamin D3. Applied biochemistry and biotechnology. 194 (2): 914-929.
27. James SL, et al. 2018. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 392 (10159): 1789-1858.
28. Jäpelt RB & Jakobsen J 2013. Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. Frontiers in plant science. 4: 136.
29. Jorde R, Sneve M, Figenschau Y, Svartberg J & Waterloo K 2008. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. Journal of internal medicine. 264 (6): 599-609.
30. Khayyatzadeh SS, et al. 2020. Dietary antioxidants and fiber intake and depressive symptoms in Iranian adolescent girls. Public health nutrition. 1-18.
31. Kimball SM, Mirhosseini N & Rucklidge J 2018. Database analysis of depression and anxiety in a community sample—Response to a micronutrient intervention. Nutrients. 10 (2): 152.
32. to a micronutrient intervention. Nutrients. 10 (2): 152.
33. Kjærgaard M, et al. 2012. Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case—control study and randomised clinical trial. British journal of psychiatry. 201 (5): 360-368.
34. Marino R & Misra M 2019. Extra-skeletal effects of vitamin D. Nutrients. 11 (7): 1460.
35. Mason C & Katzmarzyk PT 2009. Variability in waist circumference measurements according to anatomic measurement site. Obesity. 17 (9): 1789-1795.
36. Milliken SV, et al. 2012. Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function. Journal of allergy and clinical immunology. 129 (6): 1554-1561.
37. Munro BH 2005. Statistical methods for health care research. lippincott williams & wilkins.
38. Patki G, Solanki N, Atrooz F, Allam F & Salim S 2013. Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. Brain research. 1539: 73-86.
39. Peirce JM & Alviña K 2019. The role of inflammation and the gut microbiome in depression and anxiety. Journal of neuroscience research. 97 (10): 1223-1241.
40. Rucklidge J, Blampied N & Sole E 2016. Effects of Micronutrients on Anxiety and Stress in Children. In 8th World Congress of Behavioural and Cognitive Therapies, 22-25 Jun 2016.: Melbourne, Australia:.
41. Shah J & Gurbani S 2019. Association of vitamin D deficiency and mood disorders: A systematic review. In Vitamin D Deficiency (ed. F. Julia): london.
42. Sharifan P, et al. 2021a. The efficacy of dairy products fortified with nano-encapsulated vitamin D3 on physical and mental aspects of the health in obese subjects; the protocol of the SUVINA trial. Translational metabolic syndrome research. 4: 1-9.
43. Sharifan P, et al. 2021b. Effect of low-fat dairy products fortified with 1500IU nano encapsulated vitamin D3 on cardiometabolic indicators in adults with abdominal obesity: A total blinded randomized controlled trial. Current medical research and opinion. 37 (4): 579-588.
44. Slow S, et al. 2014. Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial. British medical journal. 349.
45. Sperry MF, et al. 2018. Probiotic Minas Frescal cheese added with L. casei 01: Physicochemical and bioactivity characterization and effects on hematological/biochemical parameters of hypertensive overweighted women–A randomized double-blind pilot trial. Journal of functional foods. 45: 435-443.
46. Valizadeh R, et al. 2016. A study of prevalence of anxiety in Iran: Systematic review and meta-analysis. Der Pharma Chemica. 8 (21): 48-57.
47. Vellekkatt F & Menon V 2019. Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials. J Postgrad Med. 65 (2): 74-80.
48. Wepner F, et al. 2014. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. PAIN®. 155 (2): 261-268.
49. World Health Organization 2017. Depression and other common mental disorders: global health estimates. World Health Organization.
50. Zhao G, Ford ES, Li C & Balluz LS 2010. No associations between serum concentrations of 25-hydroxyvitamin D and parathyroid hormone and depression among US adults. British journal of nutrition. 104 (11): 1696-1702.

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.