Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection that was first reported on December 31, 2019 in China . This disease behaves variously: from asymptomatic infection to influenza-like symptoms and severe acute respiratory distress syndrome (ARDS) . In the recent months, COVID-19 has infected millions and killed hundreds of thousands of patients worldwide . Human-to-human transmission of this disease happens mainly via direct contact or via droplets spread from an infected person’s cough or sneeze . The mortality rate and severity of COVID-19 are higher in elderly people and those with diabetes, cardiovascular disease, hypertension, respiratory dysfunctions, and other underlying diseases . In the crisis caused by COVID-19, the probability of publication of invalid data has increased. So, we tried to provide scientific evidences regarding the association between obesity and COVID-19. Furthermore, we aimed to investigate multiple mechanisms through which obesity may worsen the outcomes of COVID-19 using the published scientific literature