Volume 6, Issue 1 (Feb 2021)                   JNFS 2021, 6(1): 58-64 | Back to browse issues page

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Sajadi Hezaveh Z, Hadidi M, Shidfar F. The Splenectomy Effects on Lipid Profile and Glucose Metabolism in the Major Thalassemia Patients. JNFS. 2021; 6 (1) :58-64
URL: http://jnfs.ssu.ac.ir/article-1-320-en.html
Department of Human Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (688 Views)
Background: Splenectomy is a common treatment for beta thalassemia. It not only eliminates many complications by reducing the need for blood transfusion, but also causes new complications that threaten the patientschr('39') health. The aim of this study was to determine if splenectomy could alter the lipid profile and glucose metabolism in beta thalassemia major patients. Methods: In this case-control study, 41 splenectomized and 42 non-splenectomized eligible beta thalassemia patients were selected from Zafar Thalassemia Clinic, Tehran, Iran. Anthropometric, demographic, and biochemical data were collected using standard methods. Physical activity and food intake were measured using International Physical Activity Questionnaire (IPAQ) and food frequency questionnaires (FFQ), respectively. Results: Demographic characteristics and dietary intake were not significantly different between the two groups. However, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), TC/HDL-C, LDL-C/TG, and LDL-C/HDL-C ratios were significantly higher, but HDL-C was significantly lower in splenectomized patients (P < 0.05). Furthermore, fasting blood glucose (P < 0.39) and oral glucose tolerance test (P < 0.53) did not significantly differ between the two groups. Conclusions: Reduced activity of the reticuloendothelial system and reduced removal of cholesterol might be the reason for higher plasma lipid profile and greater risk of cardiovascular diseases in splenectomized patients. On the other hand, glucose metabolism was not affected by splenectomy in adult patients. To clarify this relationship, prospective studies are suggested.
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Type of article: orginal article | Subject: public specific
Received: 2020/05/6 | Accepted: 2020/06/6 | Published: 2017/11/15 | ePublished: 2017/11/15

1. Asai K 1988. Effects of splenectomy on serum lipids and experimental atherosclerosis. Angiology. 39 (6): 497-504.
2. Aviram M, Brook J, Tatarsky I, Levy Y & Carter A 1986. Increased Low-Density Lipoprotein Levels After Splenectomy: A Role for the Spleen in Cholesterol Metabolism in Myeloproliferative Disorders. American Journal of the Medical Sciences. 291 (1): 25-28.
3. Bhatia M & Cairo M 2009. Splenectomy or no splenectomy prior to allogeneic stem-cell transplantation in patients with severe thalassemia: this is the question. Pediatric transplantation. 13 (2): 143-145.
4. Bordbar M, Haghpanah S, Afrasiabi A, Dehbozorgian J & Karimi M 2012. Genotype-phenotype correlation related to lipid profile in beta-thalassemia major and intermedia in southern Iran. Journal of clinical lipidology. 6 (2): 108-113.
5. Boudrahem-Addour N, et al. 2015. Oxidative status and plasma lipid profile in beta-thalassemia patients. Hemoglobin. 39 (1): 36-41.
7. Caligiuri G, Nicoletti A, Poirier B & Hansson GK 2002. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. Journal of Clinical Investigation. 109 (6): 745-753.
8. Cappellini MD, Cohen A, Porter J, Taher A & Viprakasit V 2014. Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT). Nicosia, Cyprus: Thalassaemia International Federation.
9. Ceci A, et al. 2006. Risk factors for death in patients with beta-thalassemia major: results of a case-control study. Haematologica. 91 (10): 1420-1421.
10. Crary SE & Buchanan GR 2009. Vascular complications after splenectomy for hematologic disorders. Blood. 114 (14): 2861-2868.
11. De Sanctis V, et al. 2016. Diabetes and Glucose Metabolism in Thalassemia Major: An Update. Expert Review of Hematology. 9 (4): 401-408.
12. Dennis Robinette C & Fraumeni J 1977. Splenectomy and subsequent mortality in veterans of the 1939-45 war. Lancet. 310 (8029): 127-129.
13. Fatouros M, et al. 1995. Role of the spleen in lipid metabolism. British Journal of Surgery. 82 (12): 1675-1677.
14. Feleder C, Li Z, Perlik V, Evans A & Blatteis CM 2003. The spleen modulates the febrile response of guinea pigs to LPS. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284 (6 53-6): R1466-R1476.
15. Ge Y, et al. 1997. Relationship of Tissue and Cellular Interleukin-1 and Lipopolysaccharide after Endotoxemia and Bacteremia. Journal of Infectious Diseases. 176 (5): 1313-1321.
16. Kanichi A, Masafumi K, Michitaka N, Chiaki F & Fumio K 1988. Effects of Splenectomy on Serum Lipids and Experimental Atherosclerosis. Angiology. 39 (6): 497-504.
17. Kodama S, Kuhtreiber W, Fujimura S, Dale EA & Faustman D 2003. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science (New York, N.Y.). 302 (5648): 1223-1227.
18. Lee B, et al. 1985. Glucose tolerance test and insulin levels in children with transfusion-dependent thalassaemia. Annals of tropical paediatrics. 5 (4): 215-218.
19. Ley E, et al. 2012. Long-term effect of trauma splenectomy on blood glucose. Journal of Surgical Research. 177 (1): 152-156.
20. Moghaddam MB, et al. 2012. The Iranian Version of International Physical Activity Questionnaire (IPAQ) in Iran: content and construct validity, factor structure, internal consistency and stability. World Applied Sciences Journal. 18 (8): 1073-1080.
21. Mowla A, Karimi M, Afrasiabi A & De Sanctis V 2004. Prevalence of diabetes mellitus and impaired glucose tolerance in beta-thalassemia patients with and without hepatitis C virus infection. Pediatric Endocrinology Reviews. 2 Suppl 2: 282-284.
22. Muncie Jr HL & Campbell JS 2009. Alpha and beta thalassemia. . American Family Physician. 80 (4): 339-344.
23. Nishi M, Satendra S, Sood SK, Roshan C & Bhatia HM 2010. Frequency of β-thalassemia trait and other hemoglobinopathies in northern and western India. Indian Journal of Human Genetics. 16 (1): 16-25.
24. Petroianu A, Veloso D, Alberti L & de Souza Vasconcellos L 2008. Plasma lipid alterations after total splenectomy, subtotal splenectomy and splenic auto-implants in rats. Journal of gastroenterology and hepatology. 23 (7 Pt 2): e221-224.
25. Petroianu A, Veloso DF, Costa GR & Alberti LR 2006. [Effects of splenic surgeries on lipidogram of rats]. Revista da Associacao Medica Brasileira (1992). 52 (1): 56-59.
26. Piga A, et al. 2011. Changing patterns of splenectomy in transfusion-dependent thalassemia patients. American journal of hematology. 86 (9): 808-810.
27. Rosa T, et al. 2015. Role of leptin in body temperature regulation and lipid metabolism following splenectomy. Neuropeptides. 54: 67-72.
28. Sivitz W, Walsh S, Morgan D, Thomas M & Haynes W 1997. Effects of leptin on insulin sensitivity in normal rats. Endocrinology. 138 (8): 3395-3401.
29. Wehr E, Pilz S, Boehm BO, März W & Obermayer‐Pietsch B 2010. Association of vitamin D status with serum androgen levels in men. Clinical endocrinology. 73 (2): 243-248.
30. Yoshida M, Roth RI & Levin J 1995. The effect of cell-free hemoglobin on intravascular clearance and cellular, plasma, and organ distribution of bacterial endotoxin in rabbits. Journal of Laboratory and Clinical Medicine. 126 (2): 151-160.
31. Zuppinger K, et al. 1979. Increased risk of diabetes mellitus in beta- thalassemia major due to iron overload. Helvetica paediatrica acta. 34 (3): 197-207.

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