Volume 1, Number 1 (November 2016)                   JNFS 2016, 1(1): 17-27 | Back to browse issues page


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Asadi S, Mozaffari-Khosravi H, Naghizade M M, Nadjarzadeh A. The Effect of L-arginine Supplementation on Blood Pressure in Patients with Type 2 Diabetes: A Double-Blind Randomized Clinical Trial. JNFS. 2016; 1 (1) :17-27
URL: http://jnfs.ssu.ac.ir/article-1-28-en.html

PhD Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (964 Views)

Background: The prevalence of hypertension in patients with type 2 diabetes (T2D) is approximately twice as much as healthy people. This study was designed to determine the effect of L-arginine supplementation on blood pressure in patients with T2D. Methods: In a double-blind randomized clinical trial, 75 T2D were randomly divided into three groups (3 g/d and 6g/d of L-arginine and placebo) for 3 months. Height, weight, waist circumference, dietary intake, and blood pressure (BP) were measured before and after intervention. Results: In patients who received 3g/d L-arginine, no significant difference was observed between BP before and after the intervention, however, subgroup analysis among patients with high BP showed significant reduction in systolic (P = 0.036) and diastolic BP (P = 0.027) after L-arginine supplementation. After 3 months of intervention, systolic and diastolic BP were significantly different compared to the baseline values and also with placebo value in patients receiving 6g/d of L-arginine (P < 0.05). Conclusions: The daily intake of 6g of L-arginine for 3 months in T2D may improve BP. Taking 3g/d of this supplement may help to improve BP only in patients with hypertension.

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Type of article: orginal article | Subject: public specific
Received: 2016/05/10 | Accepted: 2016/07/13 | Published: 2016/09/4

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