Journal of Nutrition and Food Security

en Investigating Anti-Oxidative and Anti-Inflammatory Effects regarding Ethanol Extract of Allium Porrum L. in Rats with Type 2 Diabetes Mellitus public specific orginal article <div style="text-align: justify;">Type 2 diabetes mellitus (T2D) is a common endocrine and metabolic disorder worldwide. Meanwhile, Allium Porrum L. (AP) has been recognized as one of the most eminent traditional herbal medicines with substantial health benefits. The aim of the present study is to evaluate anti-oxidative and anti-inflammatory effects of ethanol extract of AP in rats with T2D. Methods: 70 male Sprague-Dawley rats were randomly divided into 7 groups of 10 animals each. The study groups were as follows: The study groups were as follows: healthy control (HC); healthy control rats receiving 100 mg/kg of AP extract (HC.AP.100); diabetic control (DC); diabetic rats receiving 10 mg/kg metformin (DT.M.10); diabetic animals receiving 50 mg/kg of AP extract (DT.AP.50); diabetic rats receiving 100 mg/kg of AP extract (DT.AP.100); and  diabetic animals receiving 200 mg/kg of AP extract (DT.AP.200). Results: After 6 weeks of intervention, the level of serum malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-α) were significantly increased (P=0.02) and (P=0.002), respectively; while superoxide dismutase (SOD) concentration was notably reduced (P=0.04) in DC.M.10 in comparison with that of the HC.AP.100 group. Also, compared to DC.M.10 group, all rats treated with metformin and AP showed a significant decrease in the level of MDA and TNF-α, along with an enhancement of SOD concentration (All P<0.001). Moreover, in comparison with DT.M.10, DT.AP.50, and DT.AP.100 treatments, the DT.AP.200 group revealed a significantly higher improvement in serum TNF-α concentration (P=0.04, P=0.003 and P=0.003, respectively). Conclusion: The findings revealed that the use of AP extract for 6 weeks may have beneficial effects on oxidative stress and inflammatory biomarkers in T2D-induced rat models</div> Oxidative stress, Inflammation, Allium porrum, Diabetes 755 760 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-417-1&slc_lang=en&sid=1 Nahid Najafi 0000-0002-9551-0278 No Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran Seyed Jalil Masoumi masoumi7415@gmail.com 0000-0001-6712-6802 Yes Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran Ali Akbar Nekooeian 0000-0001-5643-245X No Cardiovascular Pharmacology Research Lab. Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran Nader Tanideh 0000-0001-9282-1778 No 5 Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Siavash Babajafari 0000-0002-8664-7221 No Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran Hossein Khosravi-Boroujeni 0000-0003-3196-6142 No School of Medicine and Griffith Health Institute, Griffith University, QLD, Australia Najmeh Maayeshi 0000-0001-7794-2758 No Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Saeed Sherafatmanesh 0000-0003-2417-7700 No Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran