Journal of Nutrition and Food Security

en The Effects of Beta-Alanine Supplementation on Body Composition Indices: A Systematic Review and Meta-Analysis of Controlled Clinical Trials public specific review article <div style="text-align: justify;">Beta-alanine is an important oral supplement for improving athletes’ performance, followed by probable effects on body composition. Current meta-analysis was performed to investigate the role of beta-alanine supplementation on body weight, fat mass, free fat mass, and body fat percentage in adults. Methods: Web of Science, PubMed, Scopus, Cochrane library databases, and EMBASE were searched between January 1990 and May 2021. Randomized controlled trials (RCTs) comparing beta-alanine supplementation with a placebo assessing anthropometric indices were included. Meta‐analysis was performed using the random‐effects model. Publication bias was evaluated using standard methods, and subgroup analysis and meta‐regression were carried out. Results: A total of 875 articles were identified through database searching, of which 12 RCTs with 15 datasets were included in the study. This study showed that beta-alanine supplementation did not have any significant effect on body weight [SMD, 0.08; 95% CI (−0.17, 0.33); P=0.517], fat percentage [SMD, 0.09; 95% CI (−0.18, 0.37); P=0.504], fat mass [SMD, 0.10; 95% CI (−0.29, 0.50); P=0.612], and fat free mass [SMD, 0.16; 95% CI (−0.18, 0.49); P=0.517]. Conclusions: Results showed that beta-alanine supplementation does not change body composition significantly.</div> Beta alanine, Weight, Obesity, Body composition, Meta-analysis 788 801 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-113-6&slc_lang=en&sid=1 Masoud Khorshidi 0000-0002-7297-8708 No Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sanaz Jamshidi 0000-0003-2013-3663 No Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Javad Heshmati 0000-0002-2676-0185 No Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran Zohreh Sajadi Hezaveh 0000-0002-3806-8129 No Department of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia Beheshteh Olang 0000-0003-2083-9834 No Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Omid Moradi Moghaddam 0000-0003-4152-7397 No Critical Care Medicine Department, Iran University of Medical Sciences, Tehran, Iran Zahra Shahveghar No Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Zohreh Ghoreishi 0000-0001-7522-5755 No Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Alireza Ostadrahimi 0000-0002-1058-1481 No Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Meysam Zarezadeh zarezadehm@tbzmed.ac.ir 0000-0002-4268-4178 Yes Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran