en public specific orginal article <div style="text-align: justify;"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">&nbsp;Hyperuricemia is<b> </b>a condition in which uric acid level exceeds normal threshold. The pumpkin seed extract contains flavonoids that can lower uric acid level. This study aims to analyze the effect of pumpkin seeds (<i>Cucurbita moschata</i>) capsules compared to allopurinol on uric acid level in hyperuricemia patients. <b>Methods: </b>This was an experimental research with a non-randomized control group pretest-posttest design. A total of 63 patients (32 intervention and 31 control) with hyperuricemia enrolled in this study through purposive sampling technique. The intervention group (IG) was given pumpkin seeds and control group (CG), allopurinol. Data were analyzed using paired and independent sample t-test. <b>Results:</b> The result of this study showed that uric acid level significantly decreased after the pumpkin seed capsule was provided (Mean changes=-0.33 mg,dl; <i>P</i><0.001). However, allopurinol played a greater role in lowering uric acid levels (Mean changes=-0.92 mg/dl; <i>P</i><0.001). The mean changes of uric acid between groups was also significant (<i>P</i>=0.039). In addition, some of the nutrition intakes showed a significant difference after the intervention. <b>Conclusion:</b> It can be concluded from the study that pumpkin seed capsules affected the decrease of uric acid level significantly, but the number was lower compared to allopurinol. In future studies, The dose of pumpkin seed should be considered.</span></span><br> &nbsp;</div> Cucurbita, Plant Extracts, Allopurinol, Hyperuricemia 396 402 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-755-1&slc_lang=en&sid=1 Mutmainnah Mutmainnah mumutmainh@gmail.com 0009-0000-6795-3306 Yes Postgraduate Student Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Aminuddin Syam 0000-0003-4957-6003 No Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Citrakesumasari Citrakesumasari 0000-0003-2136-3890 No Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Nurhaedar Jafar 0000-0003-1578-0831 No Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Sukri Palutturi 0000-0002-1074-7445 No Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Ida Leida Maria 0000-0002-5309-2397 No Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia Andi Agus Mumang 0000-0003-1050-8812 No Postgraduate School, Hasanuddin University, Makassar, South Sulawesi, Indonesia