Journal of Nutrition and Food Security

en Comparison of 5-year Incidence of Type 2 Diabetes in Obese and Non-Obese Adult Population: The YaHs Cohort public specific orginal article <div style="text-align: justify;">Background: Obesity is an important predictor of diabetes. Defining the risk of diabetes among obese subjects is important for preventive health strategies. This study aims to compare the 5-year incidence of diabetes in obese and non-obese adult participants aged 20-70 years in a large population sample of central Iran. Methods: In this prospective study, 9964 people aged 20-70 years were selected between 2014 and 2015 using multi-stage cluster sampling from Yazd Greater Area, Iran. Participants with diabetes were excluded and non-diabetic individuals were evaluated for incident diabetes after a five-year follow-up. Logistic regression was used to find the association between obesity and 5-year incidence of diabetes in bivariate, and multivariate adjusted models for age, sex, physical activity, medical history, marital status, smoking, and education. Results: Out of the initial 9964 participants, 1383 (14%) were excluded due to prevalence of diabetes. The remaining 8413 (86.0%) participants were re-examined in 2019-2020. After five years of follow up, diabetes occurred in 6.6% (n=556) of the participants. The incidence of diabetes in obese men and women was 10.4% (n=109) and 9.9% (n=264), respectively; however, it was 4.5% (n=143) and 2.8% (n=40) in their non-obese counterparts (P<0.01). After multivariate analysis, obesity was associated with a higher likelihood of diabetes in men (OR=1.77, 95% CI: 1.33-2.35), women (OR=2.23, 95% CI: 1.55-3.21), and overall (OR=1.99, 95%CI: 1.60-2.48). Similar findings were obtained in participants aged under and over 60 years (P<0.05). Conclusion: There was a positive association between obesity and 5-year incidence of diabetes in an Iranian adult population. Interventions are required to change lifestyle in the adult population especially in younger participants to prevent obesity and diabetes. Corresponding Author:Mohammadtaghi Sarebanhassanabadi <a href="https://orcid.org/0000-0002-8867-4717" style="color:blue; text-decoration:underline">View Orcid in Profile</a> You can search for this author in <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%28Mohammadtaghi+Sarebanhassanabadi%5BAuthor%5D%29+AND+%28Yazd+Cardiovascular+Research+Center%2C+Shahid+Sadoughi+University+of+Medical+Sciences%2C+Yazd%2C+Iran%5BAuthor%5D%29&sort=">PubMed </a>   <a href="https://scholar.google.com/citations?hl=en&user=2J2mpTcAAAAJ" style="color:blue; text-decoration:underline"> Google Scholar Profile</a></div>   Diabetes, Obesity, Incidence, Cohort study 544 552 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-463-2&slc_lang=en&sid=1 Parisa Peigan 0000-0002-7580-3903 No Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Masoud Mirzaei 0000-0001-6455-0747 No Yazd Cardiovascular Research Center, Non-communicable diseases research institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Pedro Marques-Vidal 0000-0002-4548-8500 No Department of Internal Medicine, BH10-642, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland Hossein Fallahzadeh 0000-0001-6518-366X No Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Alexander Kraemer 0000-0003-2774-7860 No Department of Health Sciences, Bielefeld University, Bielefeld, Germany Mohammadtaghi Sarebanhassanabadi mtsareban@gmail.com 0000-0002-8867-4717 Yes Yazd Cardiovascular Research Center, Non-communicable diseases research institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran