Journal of Nutrition and Food Security

en The Protective Effect of Ethanolic Extract of Olive Leaf on Aluminum Phosphide-Induced Cardiac Toxicity in Rats public specific orginal article <div style="text-align: justify;">The purpose of this study is to evaluate a treatment for aluminum phosphide (ALP) poisoning, which is known as “rice tablet”. Methods: In the present study, the impact of different doses of ethanolic extract of olive leaves (100, 200, and 400 mg/kg) on ALP (120 mg/kg)-induced cardiotoxicity was evaluated in anesthetized-gastrotomized adult male Wistar rats. Thirty-five rats were randomly assigned into five groups (n=7) as follows: control (AC) and treatment groups [ALP+Olea100 (AO100), ALP+Olea 200 (AO200), and ALP+Olea 400 (AO400)]. Physiological data including blood pressure, heart rate, electrocardiogram (ECG), as well as oxidative stress markers were measured in heart tissues. Results: ALP-intoxication led to perturbed normal ECG and increased oxidative stress. Administration of olive leaf extract at various concentrations, however, mitigated bradycardia after 90 minutes, following ALP-intoxication (in AO200), hypotension (in AO100), and cardiac conduction disturbances (decreased QTC in the AO200 30 (P<0.05), 60 (P<0.001), and 90 (P<0.05) minutes after intoxication)   and decreased PR 60 (P<0.05) and 90 minutes (P<0.01) after intoxication. This was compared with baseline as well as detrimental changes in cardiac electrophysiology [mitigated ST-segment elevation  in AO200  and depressed T-wave in the AO200 (P<0.05) and  AO400 (P<0.01)  groups 90 minutes after intoxication] Conclusion: Based on these authentic results, it seems that olive leaf extracts can be useful in reducing the severity of symptoms in ALP-poisoned individuals and could be utilized in a poisoning emergency.  </div> Aluminum Compounds, Cardiotoxicity, Electrocardiography, Gastric lavage, Oxidative stress, Pesticides 449 459 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-616-1&slc_lang=en&sid=1 Maryam Moazami 0009-0006-5363-1676 No Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Mehrnoosh Sedighi 0000-0002-2002-2413 No Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran Marzieh Rashidipour 0000-0003-4024-765X No Nutritional Health Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran Sara Haydari 0009-0002-3017-9876 No Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Ghafar Ali Mahmoudi 0000-0002-1386-0654 No Department of Internal Medicine, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Saber Ghaderpour 0000-0001-5661-1650 No Department of Physiology, Tabriz Faculty of Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran Morteza Bakhshesh https://orcid.org/0000-0002-8750-4863 No Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran Afshin Nazari 0000000218631092 No Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran Maryam Moghimian moghimian.m@gmu.ac.ir 0000-0001-9181-3477 Yes Department of Physiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.