en public specific review article <div style="text-align: justify;"><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">There is a direct relationship between taking soy isoflavones and higher bone density, but there is a paucity of studies examining the relationship between flavonoid consumption and fracture risk. This study aimed to assess the bone fracture and its relationship to soy product intake by performing a systematic review. <b>Methods:</b> Scopus, PubMed, and Web of science were searched to find studies on the effect of soy isoflavones on bone fracture,</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt"> without any time and</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt"> language of publication restrictions. Key words of SoyMilk, soymilk, soybeans, soybean, soy, soya, Isoflavones, Isoflavone, ipriflavone, equol, genistein, daidzein, glycitin, fractures, and broken bone were used. <b>Results: </b>From a total of 1675 articles, 27 studies (cross-sectional studies (n=1), case-control studies (n=1), cohort (n=11), and randomized control trials (n=14)) were identified, and their quality was assessed. Eighteen studies highlighted mainly positive results in preventive influence of soy bone fractures. Two papers reported a positive effect was observed in men with cancer. No significant association was found between soy intake and bone prevention fracture in eight distinct papers. <b>Conclusion:</b> </span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Intake of soy isoflavones can make a significant preventive effect on bone fracture; however, the results of some studies are controversial</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">.&nbsp; Therefore, it is necessary to survey more studies to identify the relationship between isoflavones and bone fracture.</span></span></span></span></div> &nbsp; Isoflavones, Bone, Fracture 160 172 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-424-6&slc_lang=en&sid=1 Maryam Hamidian Shirazi 0000-0002-6927-1816 No Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Alireza Mollaei 0000-0002-1776-6315 No Department of Veterinary, Beyza branch, Islamic Azad University, Beyza, Iran Atena Ramezani 0000-0003-0400-8336 No Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Amirreza Hamidian Shirazi 0000-0001-9130-3792 Yes Department of Veterinary, Beyza branch, Islamic Azad University, Beyza, Iran Najmeh Hejazi No Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran