en public specific orginal article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:115%"><span calibri="" style="font-family:"><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It is linked to genetic and environmental factors such as nutrition. Insulin resistance (IR) is one of the major pathological changes in PCOS. This study aimed to determine the relationship between IR and macronutrient intake in PCOS subgroups. <b>Methods:</b> </span></span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">This case-control study was performed on 151 women with PCOS and were divided into four groups according to the Rotterdam diagnostic criteria: A=41, B=33, C=40, and D=37, and 31 women were also in the control group and did not have this syndrome. </span></span></span></span><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">All macronutrients</span></span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"> were assessed with a 168-item food frequency questionnaire (FFQ). </span></span></span></span><b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"> There was a significant relationship between HOMA-IR and some dietary components<br> &nbsp;(Increased calorie in group A, increased total fat intake in group C, lower intake of unsaturated fats (PUFA and MUFA) in group D and higher intake of saturated fat (SFA) and protein intake in the control group). There was no correlation in subgroup B (ovulatory phenotype). <b>Conclusion:</b> Due to the significant relationship between IR and some dietary components in PCOS subtypes, it is recommended to maintain a balance in carbohydrate and fatty acids intake, and increase dietary fiber to improve health parameters in PCOS subjects.</span></span></span></span></span></span></span></div> Macronutrient, PCOS, Insulin resistance 202 211 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-440-2&slc_lang=en&sid=1 Mahboobe Gholami 0000-0002-7930-6218 No Department of Midwifery, School of Nursing and Midwifery, Neyshabur University of Medical Sciences, Neyshabur, Iran Saeideh Ziaei No Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tehran Tarbiat Modares University, Tehran, Iran Anoshirvan Kazemnejad No Department of Biostatistics, Faculty of Medical Sciences, Tehran Tarbiat Modares University, Tehran, Iran Maryam Movahedinejad maryam.movahedinezhad@ modares.ac.ir 0000-0001-9983-3077 Yes Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tehran Tarbiat Modares University, Tehran, Iran