Journal of Nutrition and Food Security
Journal of Nutrition and Food Security
JNFS
Medical Sciences
http://jnfs.ssu.ac.ir
1
admin
2476-7417
2476-7425
en
jalali
1401
8
1
gregorian
2022
11
1
7
4
online
1
fulltext
en
The Effect of Dark Chocolate on C-Reactive Protein Level: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
public specific
review article
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span style="font-family:"Arial","sans-serif"" lang="FA"></span></span></span></span><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Background</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">: This systematic review and meta</span></span></span><span style="font-size:10.0pt"><span style="line-height:115%"><span cambria="" math="" style="font-family:">‐</span></span></span><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">analysis of randomized controlled trials (RCTs) was conducted to determine the effect of dark chocolate on </span></span></span><a href="https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/"><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="text-decoration:none"><span style="text-underline:none">C-Reactive Protein (CRP)</span></span></span></span></span></a><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> levels as one of the inflammatory factors. <b>Methods</b>: A literature search was conducted in PubMed, ISI Web of Science, Scopus, and Google Scholar up to April of 2020. The registration number of study in PROSPERO was CRD4202020072, which was conducted over 5 eligible RCTs containing a total of 330 participants. The weighted mean difference (WMD) with 95% confidence intervals was calculated for the pool effect size of CRP. The heterogeneity of studies was examined by Cochran's Q test and I-squared (I<sup>2</sup>) statistic. <b>Results</b>: Effect sizes from 330 participants based on random effect model showed no effect between consumption of dark chocolate on CRP levels compared to the control group (WMD: 0.01 mg/dl; 95% CI: −0.19, 0.22 mg/dl; <i>P</i> = 0.89; Cochran's Q test, Q statistic = 21.97; <i>P</i> < 0.001; I<sup>2</sup> = 81.80%). The results of subgroup analysis based on intervention duration and dosage showed no significant effect on CRP levels (WMD = 0.05 mg/dl, 95% CI: −0.30, 0.42 mg/dl; <i>P</i> = 0.76). Meta-regression for the intervention duration (slope: −0.0033, 95% CI: −0.0089, 0.0022; <i>P</i> = 0.24) and dosage (slope: 0.00006, 95% CI: −0.0036, 0.0037; <i>P</i> = 0.97) indicated no significant relationship with the mean difference of CRP. <b>Conclusion</b>: The results of the present meta-analysis showed that consuming dark chocolate had no significant effect on the CRP level. More clinical trials are required with higher quality and bigger sample sizes to verify the positive impact of dark chocolate on the reduction CRP level.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:115%"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span style="font-size:10.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></div>
<br>
Dark chocolate, CRP, Inflammation
562
574
http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-298-1&slc_lang=en&sid=1
Fatemeh
Yaghoubi