Journal of Nutrition and Food Security
Journal of Nutrition and Food Security
JNFS
Medical Sciences
http://jnfs.ssu.ac.ir
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2476-7417
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jalali
1401
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gregorian
2023
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The Effect of Hydroalcoholic Extract of Senna (Cassia Angustifolia Vahl.) on Lipid Profiles in Hyperlipidemic Rats
public specific
orginal article
<div style="text-align: justify;"><b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Background:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Abnormality in metabolism of lipids </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">and hyperlipidemia is a risk factor for atherosclerosis which is the major cause of cardiovascular diseases (CVDs). S</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">everal </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">herbal</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> drugs are used for the treatment of </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">dyslipidemia. </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">The present study investigates the effects of </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">hydroalcoholic extracts of Senna extract on</span></span></span> <span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">serum lipid profile </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">among hyperlipidemic rats. </span></span></span><b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> Forty eight male Wistar rats were randomly divided into 6 groups of 8 animals, including</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> group 1) normal pellet diet (control), group 2) high fat diet (HFD), group, 3) HFD with 100 mg/kg Senna extract treatment, group 4) HFD with 200</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> mg/kg Senna extract treatment</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">, group 5) 100 mg/kg pure Senna extract, </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">and</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> group 6) 200 mg/kg pure Senna extract.</span></span></span> <span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">All the dietary regimens and Senna extract treatments were continued for 30 days. </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">At the end of the experiment, </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">blood samples collected from heart of rats</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> and the lipid profile levels were measured. <b>Results:</b> The results indicated that short-term treatment by hydroalcoholic of Senna</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> extract </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">produced a significant reduction in the level of cholesterol, triglyceride, and LDL-C (<i>P</i> < 0.05), as well as an increase in HDL-C. </span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">The body weight in the HFD group was significantly higher than the other groups </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">(<i>P</i> < 0.05). <b>Conclusion:</b> </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Prescription of hydroalcoholic</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> extracts of Senna is effective in the treatment of hyperlipidemia, and can inhibit the weight gain induced by HFD in rats.</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> Some of these effects could be attributed to </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">antioxidants activities, biological and </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">pharmaceutical properties</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> and other protective properties of the Senna extract requiring further investigations</span></span></span></div>
Senna extract, Hyperlipidemia, Rat
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http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-99-3&slc_lang=en&sid=1
Mansour
Karajibani
mkarajibani@yahoo.com