Journal of Nutrition and Food Security

en The effect of quercetin on stress The Effect of Quercetin on Stress Oxidative Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trialsers; A systematic review and meta-analysis of randomized controlled clinical trials public specific review article <div style="text-align: justify;">Background: Quercetin is one of the main flavonoids, overall distributed in plants. The antioxidant capacity of quercetin is several times vitamin E and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/glutathione" style="color:blue; text-decoration:underline" title="Learn more about Glutathione from ScienceDirect's AI-generated Topic Pages">glutathione</a>. This systematic review and meta‐analysis of randomized controlled trials were performed to determine the effect of quercetin on oxidative stress (OS) markers. Methods: A literature search was conducted in PubMed, ISI Web of Science, Scopus, and Google Scholar to February of 2021. Meta-analysis was conducted on 8 eligible RCTs containing a total of 668 participants. The weighted mean difference (WMD) with 95% confidence intervals (CIs) was calculated for a pool effect size of Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), and Ferric Reducing Ability of Plasma (FRAP). Subgroup analyses were performed based on intervention duration and dosage. The heterogeneity of studies was examined by Cochran's Q test and I-squared (I2) statistic. Results: Effect sizes from 668 participants based on the random effect model showed that quercetin supplementation had no significant effect on TAC and MDA compared to the control group. The analysis illustrated that quercetin supplementation significantly increased FRAP in adults (WMD = -0.159 mmol/l, 95% confidence interval (CI):-0.178, -0.141, P ≤ 0.001). Conclusions: The finding of the current study showed that quercetin supplementation had no significant effect on TAC levels, although it significantly increased FRAP levels in adults. Also, MDA level did not markedly change. It has needed to conduct clinical trials with more quality and bigger sample sizes to verify the positive impact of quercetin on stress oxidative marker.</div> Quercetin, Oxidative stress, Malondialdehyde, Total antioxidant capacity, Ferric reducing ability of plasma 548 561 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-376-1&slc_lang=en&sid=1 Azam Ahmadi Vasmehjani 0000-0003-2764-0756 No Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatemeh Yaghoubi 0000-0001-7799-2106 No Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Zahra Darabi 0000-0001-7728-8506 No Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nooshin Abdollahi No Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Zohreh Sadat Sangsefidi 0000-0001-8185-4558 No Department of Nutrition, School of Public of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran. Mahdieh Hosseinzadeh hoseinzade.mahdie@gmail.com 0000-0001-7482-2494 Yes Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran