en public specific review article <div style="text-align: justify;"><strong><span style="font-size:10.0pt"><span style="line-height:107%"><span style="letter-spacing:-.2pt">Background</span></span></span></strong><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">: Among non-communicable diseases, cardiovascular diseases (CVDs) account for 44% of all deaths. Among natural alternatives, <i>Nigella sativa </i>(NS) exert beneficial effects on cardio-metabolic factors. This is the first systematic review and meta-analysis protocol aimed to identify all the findings relevant to the effects of NS on cardio-metabolic factors among adults. <b>Methods</b>: This study was prepared according to PRISMA-P checklist based on Cochrane Handbook for Systematic Reviews</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">of Interventions. An initial literature search was conducted in various databases using MeSH terms and related synonyms. Trials examining the effects of <i>NS</i> versus control group were included. Main outcomes consisted of blood pressure, lipid and glycemic factors, and atherogenic indices. Seven reviewers independently evaluated titles and abstracts, reviewed full texts, extracted information, and assessed the risk of bias. Methodological quality of each randomized controlled trial was assessed using the Cochrane Handbook and the GRADE system, while Newcastle-Ottawa Quality Assessment Scale was used for non-randomized studies. Continuous data of homogeneous studies were meta-analyzed via STATA. Mean differences were calculated as the effect size with 95% CIs. Heterogeneity assessment, sensitivity analysis, and publication bias were performed. <b>Conclusion<strong>: </strong></b>The quality of both randomized and non-randomized studies was assessed. The evidence from this study can provide information for future clinical trials</span></span></span></span></div> Nigella sativa, Cardio-Metabolic Factors, Systematic Review, Meta-Analysis, Insulin, Lipids, Glycemic Indices, Blood Pressure 248 255 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-104-1&slc_lang=en&sid=1 Elham Razmpoosh 0000-0001-5476-2973 No Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farhang Mirzavandi 0000-0003-0390-1667 No Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Narges Sadeghi No Department of Nutrition, School of Allied Medical Science, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Sara Safi 0000-0001-5300-1996 No Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Nooshin Abdollahi 0000-0002-3008-9013 No Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Azadeh Nadjarzadeh azadehnajarzadeh@gmail.com 0000-0002-9740-8402 Yes Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Amin Salehi-Abargouei 0000-0002-7580-6717 No Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.