en public specific orginal article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br> <b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Background:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> High blood pressure, coronary heart disease (CHD), and anxiety ailments entirely lead to many illness in patients and impose expenses on the health care system. Anxiety can significantly predict future CHD consequences. Spirulina is a known antioxidant that has a role in anxiety. The hypothesis was that Spirulina could alleviate anxiety and positively affect hypertension and its consequences. Nonetheless, there are scarce recently developed investigations on assessing the effect of consuming Spirulina on anxiety in human beings. <b>Methods: </b>The present study assessed the effect of Spirulina on anxiety in 48 Iranian patients with hypertension (female and male) aged 24&ndash;65 years in a randomized triple-blind, placebo-controlled clinical trial. The patients were given either 2 g Spirulina in the form of spirulina-fortified dressing or placebo. Anxiety levels were evaluated for each patient before and after eight weeks following consumption products with the Beck Anxiety Inventory. <b>Results:</b></span></span></span> <span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Forty-one participants completed the intervention. At the baseline, there was no significant difference in anxiety levels between groups, and they also had the same levels of stress based on the Holmes-Rahe questionnaire. The results showed no significant difference in the level of anxiety between groups after the intervention (<i>P</i> = 0.93). <b>Conclusion:</b> Although no positive results were seen in this study, this novel issue has a potential for further investigations to make comprehensive decisions.</span></span></span></div> Spirulina, Anxiety, Beck anxiety inventory, Hypertension 181 188 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-364-1&slc_lang=en&sid=1 Zohreh Ghaem Far 0000-0003-4267-0240 No Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Siavash Babajafari jafaris@sums.ac.ir 0000-0002-8664-7221 Yes Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Javad Kojuri 0000-0001-8909-897X No Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Mehran Nouri 0000-0002-7031-3542 No Students’ Research Committee, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran Elham Ashrafi-Dehkordi 0000-0002-2811-5876 No Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Seyed Mohammad Mazloomi 0000-0002-9672-7743 No Nutrition Research Center and Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran