en public specific orginal article <h3 style="text-align: justify;">&nbsp;Background: Appetite is one of the main obesity-controlling factors that can be influenced by hormones, including leptin and ghrelin. This study aimed to determine the effects of zinc supplementation on the serum levels of leptin, ghrelin, C-reactive protein (CRP), and anthropometrical indices in obese individuals with increased appetite and zinc deficiency. Methods: This study was conducted among 50 individuals with body mass index > 30 kg/m² in Shiraz, Iran in 2018. The participants were randomly allocated to the intervention that consumed one capsule containing 30 mg/day zinc (ZG) and placebo group (PG) for 3 months. Moreover, all participants were prescribed calorie-restricted diet, 500 kcal/d less than their weight maintenance requirement energy. Anthropometric indices, dietary intake, serum zinc leptin, ghrelin, and CRP were measured at the baseline and after the intervention. Results: The ccomparison of mean changes in weight (-4.56 &plusmn; 2.47, <em>P</em> < 0.0001), body mass index (-1.65 &plusmn; 0.85, <em>P</em> < 0.0001), waist circumference (-5.54 &plusmn; 4.06, <em>P</em> < 0.0001), hip circumference (-3.19 &plusmn;1.91, <em>P</em> < 0.0001), and serum zinc (15.91 &plusmn; 5.24, <em>P</em> < 0.0001) showed a significant difference between groups with greater reduction in the zinc group. However, waist to hip ratio, ghrelin, and CRP showed no significant differences. A significant difference was revealed between groups in terms of the mean leptin concentration changes, in favor of the increase in leptin concentration in ZG (<em>P</em> = 0.003). Conclusion: Based on the findings, three months of zinc supplementation improved some anthropometric and biochemical measures. Further studies are needed to confirm these results.</h3> Obesity, Zinc, Appetite, Anthropometric 377 387 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-190-1&slc_lang=en&sid=1 Narjes Zare 0000-0002-6326-7496 No Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Hassan Eftekhari h_eftekhari@yahoo.com 0000-0001-5428-1491 Yes Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Haleh Ghaem 0000-0001-9564-392X No Research Center for Health Sciences, Institute of Health, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Arash Dashtabi 0000-0001-9429-6831 No Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran