en public specific orginal article <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Background:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> The progression and pathogenesis of non-alcoholic fatty liver disease (NAFLD) are intimately connected to elevated oxidative stress and chronic inflammatory responses. With the antioxidant qualities of Ellagic acid (EA), this study aims to assay the impact of EA on inflammatory markers and adiponectin hormone in individuals with NAFLD.<b> Methods:</b><i> </i>In a double-blind, controlled clinical trial, 44 people meeting the study criteria were randomly assigned to consume 180 mg of EA per day (EAG, n=22) or placebo (PG, n=22) over an 8-week period. Measurements of anthropometric indices, food intake, physical activity levels, inflammatory markers, and adiponectin were taken at both the beginning and conclusion of the trial. The results were evaluated with the help of SPSS software. <b>Results</b><i>. </i>No meaningful statistical variations were noticed between the EA and placebo groups regarding anthropometric variables, dietary intake, or physical activity levels before and after the intervention (<i>P</i>>0.05). After receiving the supplement, the average changes of inflammatory agents, interleukin 6 (IL-6) (from 8.69&plusmn;3.07 to 5.11&plusmn;1.24 mg/dl, <i>P</i>=0.04), and tumor necrosis factor-alpha (TNF-&alpha;) (from 15.09&plusmn;3.52 to 10.61&plusmn;2.44 pg/ml, <i>P</i>=0.037), at the start and end of the study, were significantly reduced (<i>P</i><0.05). In addition, a notable increase in the level of adiponectin was noted in the EAG group (<i>P</i><0.05).<b> Conclusions.<i> </i></b>In light of the outcomes, EA can be utilized as an effective therapeutic intervention to ameliorate complications derived from NAFLD.</span></span></span></div> Ellagic acid, Inflammatory factors, Adiponectin, NAFLD. 287 296 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-1535-1&slc_lang=en&sid=1 Rasoul Samimi 0000-0001-7522-2220 No Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Mohamadreza Rashidi Nooshabadi 0000-0002-1707-0094 No Department of Pharmacology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran Sara Mighani Sara.m557@yahoo.com 0009-0001-5655-6783 Yes Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran Seyed Amir Farzam 0000-0001-5087-9381 No Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Hossein Khadem Haghighian 0000-0002-7445-1846 No Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.