en public specific orginal article <div style="text-align: justify;"><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">This study aimed to evaluate the effects of bread with and without cumin on glycemic index (GI), glycemic load (GL), and postprandial glycemic response in healthy adults. <b>Methods:</b> In this randomized clinical trial, 27 healthy participants were assigned to consume either cumin bread (made with 98% Setareh flour and 2% cumin powder) or ordinary bread (made with Setareh flour). Both breads were baked under identical conditions. Capillary blood glucose was measured at fasting and at 15, 30, 45, 60, 90, and 120 minutes after consumption. Then, GI and GL were calculated using standard methods based on glucose response and carbohydrate content. </span></span></span></span><b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">Results: </span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">Twenty participants completed the study. Cumin bread significantly reduced both GI and GL compared to ordinary bread (<i>P<</i>0.001). However, no significant differences were found between the groups in blood glucose levels at any measured time points. No adverse effects were reported following consumption of either bread. <b>Conclusion:</b> Incorporating cumin into wheat bread significantly lowers its GI and GL without affecting short-term glycemic response or causing side effects in healthy individuals</span></span></span></span></div> Bread, Cuminum, Glycemic index, Glycemic load, Persian medicine. 542 552 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-1329-1&slc_lang=en&sid=1 Seyed-Ali Khodaie 0000-0002-9016-2753 No Diabetes Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Haniyeh Nikkhah 0000-0003-0153-2044 No Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Ali Akbar Safari 0000-0003-4748-309X No Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran Nasim Namiranian 0000-0002-5133-6204 No Diabetes Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hassan Mozaffari-Khosravi 0000-0002-3513-1778 No Diabetes Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Roghaye Razavi 0000-0002-7081-4945 No Diabetes Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammad Kamalinejad afr66689@gmail.com 0000-0002-5946-4913 Yes School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran