en public specific orginal article <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Background</span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">: Type 2 diabetes mellitus (T2DM) is a prevalent and intricate disease globally. Despite various available treatments, there is no cure for it, and it is still associated with significant socioeconomic challenges. Small molecules with antioxidant activity and stabilizing effect on protein structure piqued our interest as potential antiglycating agents to decrease diabetes complications. Thus, this study aimed to evaluate and compare the antioxidant potential of Crocin with saffron aqueous extract (SAE) and two polyols (Glycerol and Myoinositol) in T2DM rats. <b>Method</b>: Neona&shy;&shy;&shy;&shy;&shy;&shy;tal male Wister rats were randomly divided into two groups. Diabetic groups at 3-5 days of birth<em> received</em> streptozotocin (STZ) (90 mg/kg) via <em>intraperitoneal</em> <em>injection</em>. After eight weeks, both groups were divided into subgroups and treated with SAE, Crocin, Glycerol, or Myoinositol. After five months, rats were sacrificed and their serum oxidative parameters and liver antioxidant enzymes were evaluated. <b>Result:</b> Crocin (100 mg/kg) significantly decreased </span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">advanced glycation end products (AGEs) and increased </span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">ferric reducing ability of plasma (FRAP)</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt"> in</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt"> serum of diabetic rats. Moreover, the reduction in liver catalase and superoxide dismutase specific activities, as well as glutathione (GSH) concentration in diabetic rats&rsquo; liver significantly increased after treatment with the same amount of Crocin. There were no significant changes in advanced oxidation protein products (AOPP) and Nitric Oxide</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt"> (</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">NO). <b>Conclusion:</b> Among the mentioned treatments, Crocin at 100 mg/kg was more effective than SAE, Glycerol, and Myoinositol in decreasing AGEs, increasing serum antioxidant capacity, and increasing the activity of hepatic antioxidant enzymes and GSH.</span></span></span></div> Type 2 diabetes, Saffron Streptozotocin, FRAP, Oxidative stress, Crocin, Glycerol, Myoinositol, Diabetic rat. 259 271 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-1249-2&slc_lang=en&sid=1 Matin Mohyadini matin.mhy@gmail.com 0009-0003-7535-5391 No Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Saeed Shirali zbatha2000@yahoo.com 0000-0001-7294-982X No Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran S. Zahra Bathaie zbatha2000@yahoo.com 0000-0002-2529-045X Yes Institute for Natural Products and Medicinal Plants (INPMP), Tarbiat Modares University, Tehran, Iran.