en public specific orginal article <div style="text-align: justify;"><b><span lang="EN-GB" style="font-size:11.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Background:</span></span></span></b><span lang="EN-GB" style="font-size:11.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> Diabetes mellitus (DM) is a metabolic syndrome and a major cause of global mortality rate and concern to health sector. Exploring therapeutic properties of natural plant has attracted array of interests in managing this challenge. This study, therefore, aimed to explore the antihyperglycemic effects of leaf extracts from <i>Artocarpus heterophyllus</i> (<i>A. heterophyllus</i>) in high sucrose diet-treated <i>Drosophila melanogaster </i>(<i>D. melanogaster</i>). <b>Methods:</b> Flies were divided into two groups of 50 flies (both sexes), i.e., i. Survival tests: with high sucrose diet; aqueous extract of <i>A. heterophyllus</i> (AEAH); ethanolic extract of <i>A. heterophyllus</i> (EEAH); and ii. Treatment groups: with AEAH, EEAH, and 30% sucrose diet. <b>Results:</b> The results showed that there was a significant (<i>P</i><0.05) increase in mortality rate, glucose and oxidative biomarkers such as H₂O₂, nitrite with a significant (<i>P</i><0.05) decrease in locomotion (negative geotaxis), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activities, as well as total thiol and GSH levels among the high-sucrose diet-treated group compared to normal flies. However, Treatment with AEAH and EEAH resulted in a significant reduction (<i>P</i><0.05) in mortality rates, glucose levels, and oxidative biomarkers. Additionally, there was a notable increase (<i>P</i><0.05) in locomotion, as well as in the activities of GPx, CAT, and SOD. This was accompanied by a rise in total thiol and GSH levels when compared to normal flies.<b> Conclusion:</b> Extracts of <i>A. heterophyllus</i> caused a reduction in mortality and enhanced locomotion in <i>D. melanogaster </i>possibly by amelioration of antioxidant imbalance and hyperglycemia.</span></span></span></div> Diabetes mellitus, Artocarpus Heterophyllus, Drosophila Melanogaster, Sucrose, Hyperglycemia. 384 397 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-1164-2&slc_lang=en&sid=1 Oyinkansola Funmilayo Olowoyo 0009-0001-3274-4456 No Department of Biochemistry, Ekiti State University, Ado-Ekiti 5363, Ado Ekiti, Ekiti State, Nigeria Olakunle Bamikole Afolabi afolabiob@abuad.edu.ng 0000-0003-4740-1779 Yes Department of Chemical Sciences, Biochemistry Programme, College of Science, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Ekiti State, Nigeria Adejoke Oluyemi Olorunlagba 0009-0007-0138-2150 No Department of Biochemistry, Ekiti State University, Ado-Ekiti 5363, Ado Ekiti, Ekiti State, Nigeria Amos Olalekan Abolaji 0000-0002-4203-452X No Department of Biochemistry, Drug Metabolism and Toxicology Unit, Faculty of Basic Medical Sciences, College of Medicine, University of lbadan, Ibadan, Oyo State, Nigeria Olusola Bolaji Adewale 0000-0001-9837-2838 No Department of Biochemistry, Drug Metabolism and Toxicology Unit, Faculty of Basic Medical Sciences, College of Medicine, University of lbadan, Ibadan, Oyo State, Nigeria Borisade Omotoso Abiodun 0000-0002-4154-9054 No Department of Crop, Horticulture and Landscape Design, Ekiti State University, Ado-Ekiti 5363, Ado Ekiti, Ekiti State, Nigeria Omotade Ibidun Oloyede 0000-0002-6111-0559 No Department of Biochemistry, Ekiti State University, Ado-Ekiti 5363, Ado Ekiti, Ekiti State, Nigeria