en public specific review article <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">Background:</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt"> The current data on the association between dietary polyphenols intake and liver cancer are not conclusive. Therefore, we aimed to perform a systematic review and meta-analysis of observational studies on the association between dietary polyphenol intake and liver cancer. <b>Methods: </b>A systematic search of online databases, including PubMed/MEDLINE, Scopus, and Web of Science, was conducted until August 2024. Observational studies that investigated the association between dietary intake of polyphenols and the risk of liver cancer were included. The overall effects were assessed using the random effects model. <b>Results: </b>Totally, four studies were eligible to be included in the systematic review, and for meta-analysis, 3 studies with 4 effect sizes were included</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">. The overall association between dietary intake of isoflavones and the risk of liver cancer was not significant (</span></span></span></span><i><span lang="EN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">P</span></span></span></span></i><span lang="EN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">=0.35, 95% CI: </span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">0.58-1.21</span></span></span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">)</span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.1pt">. <b>Conclusion: </b>No significant association was found between dietary polyphenols intake and liver cancer risk. Further observational studies are suggested to confirm these findings.</span></span></span></span></div> Polyphenols, Isoflavones, Liver neoplasms, Hepatocellular cancer. 328 337 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-1131-1&slc_lang=en&sid=1 Arezoo sadat Emrani arezooemrani.ae@gmail.com 0000-0002-2909-3314 No Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatemeh Mirjalili mirjalilifatemeh1372@gmail.com 0000-0003-1130-6294 No Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hooman Yekrang Safakar loodvik_hys@yahoo.com 0009-0004-41231-6675 No Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Bita Forootani bita.frt@gmail.com 0009-0001-8598-2714 No Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Amin Salehi-abargouei abargouei@gmail.com 0000-0002-7580-6717 Yes Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran