Journal of Nutrition and Food Security

en Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study public specific orginal article <div style="text-align: justify;">Background: Gastric cancer (GC) is the most common cancer among Iranian men. A diet rich in antioxidant compounds has been offered as an appropriate strategy for reducing the risk of GC. This study aimed to determine the possible association between dietary total antioxidant capacity (dTAC) and the Iranian population's GC risk. Methods: In total, 178 newly diagnosed GC patients and 238 healthy controls were recruited for this hospital-based case-control study. Dietary intakes were collected using a validated 146-item diet history questionnaire (DHQ), and dTAC was analyzed using Ferric reducing antioxidant potential (FRAP) assay. Results: The mean value of dTAC was 10.42±5.42 for cases and 11.42±5.86 for controls. Black tea, fruits, and cereals consumption were the main contributors to dTAC in both groups. DTAC was associated with a reduction in the risk of GC (OR 0.54; 95%CI: 0.31–0.92) (second vs. lowest tertile). This association did not change after adjustment for body mass index, education, energy intake, smoking, and Helicobacter pylori infection (0.55; 95% CI: 0.31-0.99). There was no significant association between fruits, vegetables, nuts, and legumes TAC with GC. Conclusion: The whole intake of dTAC from different food sources was not high in the population; however, this amount showed a preventive effect against GC. </div> Case-Control, Diet, FRAP, Stomach neoplasms, Total antioxidant capacity. 15 22 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-512-1&slc_lang=en&sid=1 Saba Narmcheshm 0000-0003-3277-6041 No Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Toorang 0000-0002-1969-4749 No Departments of Medical and Surgical Sciences, University of Bologna, Italy Bahareh Sasanfar 0000-0002-9560-1049 No Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Maryam Hadji 0000-0001-5486-7513 No A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70150, Finland Ahmadreza Dorosty Motlagh 0000-0002-2249-756X No Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Kazem Zendehdel kzendeh@tums.ac.ir 0000-0002-0269-4945 Yes Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran