Journal of Nutrition and Food Security

en Effect of Zinc Gluconate Supplementation on C-Reactive Protein and Malondialdehyde in Patients with Behcet's Disease: A Double-Blind Randomized Controlled Clinical Trial public specific orginal article <div style="text-align: justify;">Background:  Behçet's disease (BD) with autoimmune and auto-inflammatory nature is more prevalent in Silk Road countries. The current study aimed to investigate the effect of zinc gluconate supplementation on C-reactive protein (CRP) and malondialdehyde (MDA) levels in BD patients. Methods: This randomized controlled clinical trial was conducted on 50 Iranian BD patients. Participants were randomly assigned into either placebo or zinc gluconate (30 mg/day) groups for 12 weeks. Before and after the intervention, serum MDA and CRP levels were measured. Results: Zinc supplementation led to a significant increase in serum zinc levels compared to the placebo group (P<0.05). There was no significant difference in MDA serum levels between the groups after adjusting for the baseline values and confounding factors (P>0.05). Zinc supplementation led to a significant improvement in CRP serum levels compared to the placebo group following adjustment for the effect of baseline values and confounding factors (P=0.012 and 0.04, respectively). Conclusion: Zinc supplementation in an elemental dose of 30 mg per day has an anti-inflammatory effect in BD patients by reducing CRP levels. The beneficial effect of zinc on lipid peroxidation in BD patients was not shown in the study.  </div> Malondialdehyde, Zinc, CRP, Behcet disease. 194 203 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-257-2&slc_lang=en&sid=1 Amir Hossein Faghfouri Amir.nut89@gmail.com No Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran Seyyed Morteza Seyyed Shoura Shouramor@gmail.com No Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Ghazaleh shahhosseini Ghh1378@gmail.com No Department of Dentistry, Islamic Azad university, Tehran, Iran Amir Arshia Khodabandehloo Arshiyakhodabandehloo.srbia@gmail.com No 4Department of Converging Sciences and Technologies, Islamic Azad University Science and Research Branch ,Tehran, Iran Pourya Fathollahia No Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Alireza Khabbazi Khabbazi@gmail.com No Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Vali Musazadeh mosazadeh.vali05@gmail.com No Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Beitullah Alipour alipourb@tbzmed.ac.ir Yes Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran