Volume 2, Issue 2 (May 2017)                   JNFS 2017, 2(2): 179-182 | Back to browse issues page

XML Print

, Professor of Nutritional Sciences, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (2899 Views)

Background: In acute lymphoblastic leukemia (ALL) the bone marrow loses its ability in the differentiation and maturation of blood cells at different stages. Zinc and copper are important co-factors for several enzymes and play an important role in maintenance of DNA integrity. Changes in serum levels of zinc and copper have been found in lymphoproliferative disorders. In the present study, the aim was to compare serum levels of zinc, copper, vitamin D, and inflammatory markers after eight courses of chemotherapy. Methods: Participants of this study included 30 ALL patients in the age range of 15 to 65 years. A 10 mL blood sample was taken before and after eight courses of chemotherapy. The concentration of Zinc, Copper, hs-CRP, vitamin D and malondialdehyde (MDA) were measured. Results: There was a significant increase in serum zinc (121.7 ± 18.05 µg/dL before chemotherapy and 156.6 ± 25.00 µg/dL after chemotherapy) and a significant decrease in serum copper (661.9 ± 190.1 µg/dL before chemotherapy and 402.2 ± 93.5 µg/dL after chemotherapy) and a significant decrease in Malondialdehyde and serum vitamin D were observwd. Further, no significant differences were observed in hs-CRP after chemotherapy. Conclusion: Results showed that chemotherapy could decrease the burden of disease by increasing serum zinc and decreasing serum copper. 

Full-Text [PDF 361 kb]   (2028 Downloads) |   |   Full-Text (HTML)  (731 Views)  
Type of article: orginal article | Subject: public specific
Received: 2016/10/24 | Published: 2017/05/1 | ePublished: 2017/05/1

1. Avisar A, et al. 2012. Chemotherapy-related cognitive impairment: does integrating complementary medicine have something to add? Review of the literature. Breast cancer research and treatment. 136 (1): 1-7.
2. Beguin Y, et al. 1987. Observations of serum trace elements in chronic lymphocytic leukemia. Cancer. 60 (8): 1842-1846.
3. Carpentieri U, Myers J, Thorpe L, Daeschner CW & Haggard ME 1986. Copper, zinc, and iron in normal and leukemic lymphocytes from children. Cancer research. 46 (2): 981-984.
4. de Carvalho G, Camilo ME & Ravasco P 2011. What is the relevance of nutrition in oncology? Acta m├ędica portuguesa. 24: 1041-1050.
5. Demir C, et al. 2011. Altered serum levels of elements in acute leukemia cases in Turkey. Asian pacific journal of cancer prevention. 12: 3471-3474.
6. Faderl S, Kantarjian HM, Talpaz M & Estrov Z 1998. Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia. Blood. 91 (11): 3995-4019.
7. Fisher G & Shifrine M 1978. Hypothesis for the mechanism of elevated serum copper in cancer patients. Oncology. 35 (1): 22-25.
8. Hoffman R, Silberstein LE, Heslop H, Weitz J. Hematology: basic principles and practice; 2013. 6th edn. Chapter 65: 960-980.e12
9. Lee S, Choe J-W, Kim H-K & Sung J 2011. High-sensitivity C-reactive protein and cancer. journal of epidemiology. 21 (3): 161-168.
10. Mehde AA & Yousif AM 2014. Estimation of Malondialdehyde, Total Antioxidant Capacity and Some Biochemical Parameters in CSF and Sera of Patients with Acute Lymphoblastic Leukemia. Australian journal of basic and applied sciences. 8 (15): 329-333.
11. Radhakrishnan N, et al. 2013. Antioxidant levels at diagnosis in childhood acute lymphoblastic leukemia. The Indian journal of pediatrics. 80 (4): 292-296.
12. Sgarbieri UR, Fisberg M, Tone LG & Latorre MdRD 2006. Nutritional assessment and serum zinc and copper concentration among children with acute lymphocytic leukemia: a longitudinal study. Sao paulo medical journal. 124 (6): 316-320.
13. Shils ME & Shike M 2006. Modern nutrition in health and disease. Lippincott Williams & Wilkins.
14. Valko M, Rhodes C, Moncol J, Izakovic M & Mazur M 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions. 160 (1): 1-40.
15. Zuo X, Chen J, Zhou X, Li X & Mei G 2006. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Biological trace element research. 114 (1-3):
16. 41-53.

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.