Volume 7, Issue 4 (NOV 2022)
JNFS 2022, 7(4): 548-561 |
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Azam Ahmadi Vasmehjani 
, Fatemeh Yaghoubi , Zahra Darabi , Nooshin Abdollahi , Zohreh Sadat Sangsefidi , Mahdieh Hosseinzadeh *
, Fatemeh Yaghoubi , Zahra Darabi , Nooshin Abdollahi , Zohreh Sadat Sangsefidi , Mahdieh Hosseinzadeh *
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (1351 Views)
Background: Quercetin is one of the main flavonoids, overall distributed in plants. The antioxidant capacity of quercetin is several times vitamin E and glutathione. This systematic review and meta‐analysis of randomized controlled trials were performed to determine the effect of quercetin on oxidative stress (OS) markers. Methods: A literature search was conducted in PubMed, ISI Web of Science, Scopus, and Google Scholar to February of 2021. Meta-analysis was conducted on 8 eligible RCTs containing a total of 668 participants. The weighted mean difference (WMD) with 95% confidence intervals (CIs) was calculated for a pool effect size of Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), and Ferric Reducing Ability of Plasma (FRAP). Subgroup analyses were performed based on intervention duration and dosage. The heterogeneity of studies was examined by Cochran's Q test and I-squared (I2) statistic. Results: Effect sizes from 668 participants based on the random effect model showed that quercetin supplementation had no significant effect on TAC and MDA compared to the control group. The analysis illustrated that quercetin supplementation significantly increased FRAP in adults (WMD = -0.159 mmol/l, 95% confidence interval (CI):-0.178, -0.141, P ≤ 0.001). Conclusions: The finding of the current study showed that quercetin supplementation had no significant effect on TAC levels, although it significantly increased FRAP levels in adults. Also, MDA level did not markedly change. It has needed to conduct clinical trials with more quality and bigger sample sizes to verify the positive impact of quercetin on stress oxidative marker.
Keywords: Quercetin, Oxidative stress, Malondialdehyde, Total antioxidant capacity, Ferric reducing ability of plasma
Type of article: review article |
Subject:
public specific
Received: 2021/05/27 | Published: 2022/11/19 | ePublished: 2022/11/19
Received: 2021/05/27 | Published: 2022/11/19 | ePublished: 2022/11/19
References
1. Abbey EL & Rankin JW 2011. Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation. International journal of sport nutrition and exercise metabolism. 21 (2): 91-96.
2. Barja G 2013. Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxidants & redox signaling. 19 (12): 1420-1445.
3. Basu S 2008. F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications. Antioxidants & redox signaling. 10 (8): 1405-1434.
4. Bazzucchi I, et al. 2019. The effects of quercetin supplementation on eccentric exercise-induced muscle damage. Nutrients. 11 (1): 205.
5. Birben E, Sahiner UM, Sackesen C, Erzurum S & Kalayci O 2012. Oxidative stress and antioxidant defense. World allergy organization journal. 5 (1): 9-19.
6. Boots AW, Drent M, de Boer VC, Bast A & Haenen GR 2011. Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clinical nutrition. 30 (4): 506-512.
7. Brüll V, et al. 2015. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertension: a randomised double-blinded placebo-controlled cross-over trial. British journal of nutrition. 114 (8): 1263-1277.
8. Cao G, Sofic E & Prior RL 1997. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free radical biology and medicine. 22 (5): 749-760.
9. Di AC, et al. 2008. Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population. Journal of nutrition. 138 (10): 1939-1945.
10. Egert S, et al. 2009. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. British journal of nutrition. 102 (7): 1065-1074.
11. Egert S, et al. 2008. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. Journal of nutrition. 138 (9): 1615-1621.
12. Finkel T 2003. Oxidant signals and oxidative stress. Current opinion in cell biology. 15 (2): 247-254.
13. Ghosh A, Mandal AK, Sarkar S, Panda S & Das N 2009. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life sciences. 84 (3-4): 75-80.
14. Gibellini L, et al. 2010. Interfering with ROS metabolism in cancer cells: the potential role of quercetin. Cancers. 2 (2): 1288-1311.
15. Granado-Serrano AB, Martín MA, Bravo L, Goya L & Ramos S 2006. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). Journal of nutrition. 136 (11): 2715-2721.
16. Haghighat N, et al. 2013. The effects of dark chocolate on lipid profile, apo-lipoprotein A-1, apo-lipoprotein B and inflammation in type-2 diabetic patients: A randomized clinical trial. Iranian journal of nutrition sciences & food technology. 8 (2): 21-30.
17. Halliwell B 2000. Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? Cardiovascular research. 47 (3): 410-418.
18. Harwood M, et al. 2007. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food and chemical toxicology. 45 (11): 2179-2205.
20. Higgins JP & Thompson SG 2002. Quantifying heterogeneity in a meta‐analysis. Statistics in medicine. 21 (11): 1539-1558.
21. Huang H, Liao D, Dong Y & Pu R 2020. Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis. Nutrition reviews.
22. Lee EJ, et al. 2007. Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. Experimental & molecular medicine. 39 (4): 469-476.
23. Liberati A, et al. 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of clinical epidemiology. 62 (10): e1-e34.
24. Linke A, et al. 2005. Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. Circulation. 111 (14): 1763-1770.
25. Liu C-M, Ma J-Q & Sun Y-Z 2010. Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead. Environmental toxicology and pharmacology. 30 (3): 264-271.
26. Loke WM, et al. 2008. Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. American journal of clinical nutrition. 88 (4): 1018-1025.
27. Lorzadeh E, Ramezani-Jolfaie N, Mohammadi M, Khoshbakht Y & Salehi-Abargouei A 2019. The effect of hesperidin supplementation on inflammatory markers in human adults: a systematic review and meta-analysis of randomized controlled clinical trials. Chemico-biological interactions. 307: 8-15.
28. McAnulty SR, et al. 2008. Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Applied physiology, nutrition, and metabolism. 33 (2): 254-262.
29. Ou Q, Zheng Z, Zhao Y & Lin W 2020. Impact of quercetin on systemic levels of inflammation: A meta-analysis of randomised controlled human trials. International Journal of Food Sciences and Nutrition. 71 (2): 152-163.
30. Raja SB, et al. 2017. Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression. Food and chemical toxicology. 106: 92-106.
31. Riva A, Ronchi M, Petrangolini G, Bosisio S & Allegrini P 2019. Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin. European journal of drug metabolism and pharmacokinetics. 44 (2): 169-177.
32. Sangsefidi ZS, Yaghoubi F, Hajiahmadi S & Hosseinzadeh M 2020. The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials. Food science & nutrition. 8 (4): 1766-1776.
33. Scholten SD & Sergeev IN 2013. Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners. Open access journal of sports medicine. 4: 53.
34. Sepidarkish M, et al. 2019. The effect of vitamin D supplementation on oxidative stress parameters: a systematic review and meta-analysis of clinical trials. Pharmacological research. 139: 141-152.
35. Shanely RA, et al. 2010. Quercetin supplementation does not alter antioxidant status in humans. Free radical research. 44 (2): 224-231.
36. Sties SW, et al. 2018. Influence of exercise on oxidative stress in patients with heart failure. Heart failure reviews. 23 (2): 225-235.
37. Tabrizi R, et al. 2020. The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition. 60 (11): 1855-1868.
38. van't Erve TJ 2018. Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α. Redox biology. 17: 284-296.
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