Volume 7, Issue 1 (Feb 2022)                   JNFS 2022, 7(1): 129-135 | Back to browse issues page

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Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:   (924 Views)
Artichoke (Cynara scolymus L.) is a perennial plant native to the southern Mediterranean region of North Africa. Today, artichokes are widely grown around the world and buds of artichokes are used as a vegetable all over the world. This plant is widely used in the traditional medicine. Artichoke has antioxidant and anti-inflammatory effects, and countless medicinal properties. Artichoke inhabits reactive oxygen species (ROS) and free radicals due to phenolic acids and flavonoid compounds and also suppresses the activation pathway of NF-κB, thereby could reduce oxidative stresses, inflammatory factors, and prevent suppressing red blood cells probably. It has also been suggested for traditional medicine including blood purification, so it can be used for anemia treatment.
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Type of article: short communication | Subject: public specific
Received: 2021/02/16 | Accepted: 2021/03/10 | Published: 2022/01/22 | ePublished: 2022/01/22

1. Ahmadi A, Heidarian E & Ghatreh-Samani K 2019. Modulatory effects of artichoke (Cynara scolymus L.) leaf extract against oxidative stress and hepatic TNF-α gene expression in acute diazinon-induced liver injury in rats. Journal of basic and clinical physiology and pharmacology. 30 (5).
2. Andlid TA, D’Aimmo MR & Jastrebova J 2018. Folate and Bifidobacteria. In Bifidobacteria and related organisms, pp. 195-212. Elsevier.
3. Aslan M, et al. 2006. Lymphocyte DNA damage and oxidative stress in patients with iron deficiency anemia. Mutation research/fundamental and molecular mechanisms of mutagenesis. 601 (1-2): 144-149.
4. Betancor‐Fernández A, Pérez‐Gálvez A, Sies H & Stahl W 2003. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. Journal of pharmacy and pharmacology. 55 (7): 981-986.
5. Cavaillon J-M 2001. Pro-versus anti-inflammatory cytokines: myth or reality. Cellular and molecular biology-Paris-Wegmann. 47 (4): 695-702.
6. Ceccarelli N, et al. 2010. Globe artichoke as a functional food. Mediterranean journal of nutrition and metabolism. 3 (3): 197-201.
7. Felli N, et al. 2005. Multiple members of the TNF superfamily contribute to IFN-γ-mediated inhibition of erythropoiesis. Journal of immunology. 175 (3): 1464-1472.
8. Fibach E & Rachmilewitz E 2008. The role of oxidative stress in hemolytic anemia. Current molecular medicine. 8 (7): 609-619.
9. Ganz T & Nemeth E 2009. Iron sequestration and anemia of inflammation. In Seminars in hematology, pp. 387-393. Elsevier.
10. García-Lafuente A, Guillamón E, Villares A, Rostagno MA & Martínez JA 2009. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflammation research. 58 (9): 537-552.
12. Hebbel RP, Eaton J, Balasingam M & Steinberg MH 1982. Spontaneous oxygen radical generation by sickle erythrocytes. Journal of clinical investigation. 70 (6): 1253-1259.
13. Jimenez-Escrig A, Dragsted LO, Daneshvar B, Pulido R & Saura-Calixto F 2003. In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats. Journal of agricultural and food chemistry. 51 (18): 5540-5545.
14. Jun N-J, et al. 2007. Radical scavenging activity and content of cynarin (1, 3-dicaffeoylquinic acid) in Artichoke (Cynara scolymus L.). Journal of applied biological chemistry. 50 (4): 244-248.
15. Klings ES & Farber HW 2001. Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease. Respiratory research. 2 (5): 1-6.
16. Kobbe P, et al. 2012. Inhalative IL-10 attenuates pulmonary inflammation following hemorrhagic shock without major alterations of the systemic inflammatory response. Mediators of inflammation. 2012.
17. Liorach R, Espin JC, Tomas-Barberan FA & Ferreres F 2002. Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics. Journal of agricultural and food chemistry. 50 (12): 3458-3464.
18. Macdougall IC & Cooper AC 2002. Erythropoietin resistance: the role of inflammation and pro‐inflammatory cytokines. Nephrology dialysis transplantation. 17 (suppl_11): 39-43.
19. Mahboubi M 2018. Cynara scolymus (artichoke) and its efficacy in management of obesity. Bulletin of faculty of pharmacy, Cairo University. 56 (2): 115-120.
20. Majeed MF, Numan IT & Noori M 2015. Study the anti-inflammatory activity of artichoke (cynara scolymus) different extracts in experimentel models of acute inflammation in rats. Pharmacie globale. 6 (4): 1.
21. Marks PW 2019. Anemia: clinical approach. In Concise Guide to Hematology, pp. 21-27. Springer.
22. Mccord JM 1993. Human disease, free radicals, and the oxidant/antioxidant balance. Clinical biochemistry. 26 (5): 351-357.
23. Miláčková I, Kapustová K, Mučaji P & Hošek J 2017. Artichoke leaf extract inhibits AKR1B1 and reduces NF-κB activity in human leukemic cells. Phytotherapy research. 31 (3): 488-496.
24. Mohamed SH, Ahmed HH, Farrag ARH, Abdel-Azim NS & Shahat AA 2013. Cynara scolymus for relieving on nonalcoholic steatohepatitis induced in rats. International journal of pharmacy and pharmaceutical sciences. 5: 57-66.
25. Moll R & Davis B 2017. Iron, vitamin B12 and folate. Medicine. 45 (4): 198-203.
26. Negro D, et al. 2012. Polyphenol compounds in artichoke plant tissues and varieties. Journal of food science. 77 (2): C244-C252.
27. Nemeth E, et al. 2004a. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. Journal of clinical investigation. 113 (9): 1271-1276.
28. Nemeth E, et al. 2004b. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 306 (5704): 2090-2093.
29. Pandino G, Lombardo S, Mauromicale G & Williamson G 2011a. Phenolic acids and flavonoids in leaf and floral stem of cultivated and wild Cynara cardunculus L. genotypes. Food chemistry. 126 (2): 417-422.
30. Pandino G, Lombardo S, Mauromicale G & Williamson G 2011b. Profile of polyphenols and phenolic acids in bracts and receptacles of globe artichoke (Cynara cardunculus var. scolymus) germplasm. Journal of food composition and analysis. 24 (2): 148-153.
31. Pérez-García F, Adzet T & Cañigueral S 2000. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free radical research. 33 (5): 661-665.
32. Pourmorad F, Hosseinimehr S & Shahabimajd N 2006. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. African journal of biotechnology. 5 (11).
33. Premaratna S, et al. 2012. Angiotensin-converting enzyme inhibition reverses diet-induced obesity, insulin resistance and inflammation in C57BL/6J mice. International journal of obesity. 36 (2): 233-243.
34. Premkumar S, Ramanan PV & Thanka J 2018. Anaemia in school children-looking beyond iron deficiency. Journal of evolution of medical and dental sciences. 7 (45): 4884-4887.
35. Rice-Evans C, Omorphos SC & Baysal E 1986. Sickle cell membranes and oxidative damage. Biochemical journal. 237 (1): 265-269.
36. Robards K 2003. Strategies for the determination of bioactive phenols in plants, fruit and vegetables. Journal of chromatography A. 1000 (1-2): 657-691.
37. Rodriguez R, et al. 2014. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infection and immunity. 82 (2): 745-752.
38. Rondanelli M, Monteferrario F, Perna S, Faliva MA & Opizzi A 2013. Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action. Monaldi archives for chest disease. 80 (1).
39. Rouhi-Boroujeni H, Gharipour M, Mohammadizadeh F, Ahmadi S & Rafieian-Kopaei M 2015. Systematic review on safety and drug interaction of herbal therapy in hyperlipidemia: a guide for internist. Acta bio-medica: Atenei parmensis. 86 (2): 130-136.
40. Salem MB, et al. 2015. Pharmacological studies of artichoke leaf extract and their health benefits. Plant foods for human nutrition. 70 (4): 441-453.
41. Sallam S, et al. 2008. Nutritive value assessment of the artichoke (Cynara scolymus) by-product as an alternative feed resource for ruminants. Tropical and subtropical agroecosystems. 8 (2): 181-189.
42. Santos HO, Bueno AA & Mota JF 2018. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacological research. 137: 170-178.
43. Tang X, Wei R, Deng A & Lei T 2017. Protective effects of ethanolic extracts from artichoke, an edible herbal medicine, against acute alcohol-induced liver injury in mice. Nutrients. 9 (9): 1000.
44. Valladares-Cisneros M, Esquivel-Rojas A, Salinas-Bravo V & Gonzalez-Rodríguez J 2016. Use of Cynara Scolymus as green corrosion inhibitor for Carbon Steel in Sulfuric Acid. International journal of electrochemical science. 11: 8067-8081.
45. Wang M, et al. 2003. Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). Journal of agricultural and food chemistry. 51 (3): 601-608.
46. Zapolska-Downar D, et al. 2002. Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes. Life sciences. 71 (24): 2897-2908.

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