Background: The prevalence of overweight and obesity is increasing among women. Since diet quality and quality of life are two indicators of healthy lifestyle, we conducted this study to examine the relationship between these two indicators among overweight and obese women. Methods: This study was carried out among a sample of 111 overweight and obese women, aged 35-60 years in the west of Tehran, Iran. Dietary data were collected using a 168-item food frequency questionnaire and the Nutrient-Rich Food index (NRF9.3) algorithms were used to estimate the nutrient density. The quality of life was measured using 26-item WHOQOL-BREF questionnaire.  The SPSS 24 was run for statistical analysis. Results: We found that the participants’ quality of life had a significant relationship with their occupational, marital, and educational status, but no significant association was observed between the quality of life and diet quality (P = 0.50). Pearson correlation showed that NRF9.3 score was positively associated with body mass index (P = 0.01), but no difference was found between obese and overweight women regarding quality of life. Conclusion: The NRF9.3 index was not associated with WHOQOL-BREF questionnaire's score, while job, marriage, and education were significantly associated with the quality of life. Further studies are needed to clarify the relationship between quality of life and diet quality among overweight and obese women