Volume 10, Issue 3 (Aug 2025)
JNFS 2025, 10(3): 433-440 |
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Hoseini F S, Mirhosseini S S, Djazayery A, Movahedi A. Association between Serum Albumin and Mortality in Delta COVID-19 Patients in ICU and General Ward. JNFS 2025; 10 (3) :433-440
URL: http://jnfs.ssu.ac.ir/article-1-1216-en.html
URL: http://jnfs.ssu.ac.ir/article-1-1216-en.html
Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract: (231 Views)
Background: Coronavirus disease (COVID-19) primarily affects the respiratory system, with a mortality rate of 1.4 to 4%. Albumin, an acute-phase reactant protein with antioxidant properties, plays a key role in health assessment. Low serum albumin levels often indicate malnutrition, disease, or infection. This study examines the relationship between serum albumin levels and mortality in COVID-19 patients. Methods: This study is a retrospective cross-sectional analysis of 793 COVID-19 patients categorized into two groups based on serum albumin levels: hypoalbuminemia and normal albumin. Mortality rate, background diseases (e.g., hypertension, diabetes, chronic obstructive pulmonary disease (COPD), cancer, cardiovascular disease), c-reactive protein, hospitalization duration, platelets, lymphocytes, and neutrophils were evaluated. The correlation between serum albumin levels and mortality was analyzed both independently and after adjusting for confounding factors to assess its impact on patient outcomes. Results: The results showed that the average duration of hospitalization, as well as neutrophil, lymphocyte, and platelet count was higher in hypoalbuminemia group. Although the average time of hospitalization and neutrophils in two groups did not differ (P>0.05), lymphocytes and platelets were significantly different in two groups (P<0.05). A significant interaction was observed between serum albumin and mortality in patients. These associations remained significant after adjusting for age, sex, underlying diseases, and the number of COVID-19 vaccine doses received (P=0.0001). Conclusions: Serum albumin levels is associated with the mortality rate in patients infected with delta coronavirus. It is recommended that future prospective studies evaluate the relationship between serum albumin levels and mortality rates
Keywords: COVID-19, Mortality, Serum albumin, Hypoalbuminemia, Critical illness, Inflammatory markers.
Type of article: orginal article |
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public specific
Received: 2024/12/25 | Published: 2025/07/6 | ePublished: 2025/07/6
Received: 2024/12/25 | Published: 2025/07/6 | ePublished: 2025/07/6
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