Journal of Nutrition and Food Security

en BMI and Systemic Inflammation Mediating the Gender-Specific Association between Food Insecurity and Circadian Syndrome in US Adults: A Cross-sectional Study from the NHANCE public specific orginal article <div style="text-align: justify;">Background: This study aimed to investigate gender-specific associations between food insecurity (FI) and circadian syndrome (CircS) among US adult, and to explore whether body mass index (BMI) and systemic inflammation [white blood cell (WBC) count] mediate these associations. Methods: Cross-sectional data from 12, 601 participants (≥20 yers) in the National Health and Nutrition Examination Survey (NHANES) 2005–2016 survey were analyzed. FI was assessed using the United States Department of Agriculture food security scale module. CircS was defined as the presence of ≥4 of the following components: central obesity, hypertension, elevated fasting glucose, reduced HDL-C, elevated triglycerides, short sleep duration, and depressive symptoms. Finally, weighted logistic regression and mediation analyses were performed to evaluate associations between FI and CircS, and the mediating roles of BMI and WBC count. Results: FI was significantly associated with increased odds of CircS [Adjusted odds ratio (AOR)]: 1.46; 95% confidence interval [CI]: 1.26–1.70), particularly among women (AOR: 1.69; 95% CI: 1.39–2.05). BMI and WBC count partially mediated this relationship in women, accounting for 37.5% and 18.6% of the total effect, respectively. Conclusions: The findings highlight the role of metabolic and inflammatory dysregulation, particularly among women, as potential mechanisms linking FI and circadian health disturbances. Targeting FI through public health strategies that address these pathways may reduce the burden of CircS and related condition, and support the integration of circadian health into nutrition and chronic disease prevention policies.</div> Food insecurity, NHANES,Circadian syndrome, Body mass index (BMI),White blood cell count 297 312 http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-1557-1&slc_lang=en&sid=1 Jiawei Su No Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China Senfeng Guo No Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China Jundan Wang No Experimental Teaching Center of Preventive Medicine, School of Public Health, Southern Medical University, (Guangdong Provincial Key Laboratory of Tropical Disease Research), National Preventive Medicine Experimental Teaching Demonstration Center, Guangzhou 510515, Guangdong, China. Tingyu Wang No Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China Ronghua Mo No Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China He Wang No Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China Hua Li No Experimental Teaching Center of Preventive Medicine, School of Public Health, Southern Medical University, (Guangdong Provincial Key Laboratory of Tropical Disease Research), National Preventive Medicine Experimental Teaching Demonstration Center, Guangzhou 510515, Guangdong, China Jufeng Ye yjfws@163.com 0009-0000-3859-0147 Yes Experimental Teaching Center of Preventive Medicine, School of Public Health, Southern Medical University, (Guangdong Provincial Key Laboratory of Tropical Disease Research), National Preventive Medicine Experimental Teaching Demonstration Center, Guangzhou 510515, Guangdong, China.