Volume 2, Issue 2 (May 2017)                   JNFS 2017, 2(2): 165-172 | Back to browse issues page

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Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (559 Views)

Background: Sexual dysfunction is an important health problem which prevalence in patients with type 2 diabetes (T2D) is higher than other people. The aim of this study was to evaluate the effect of L-arginine oral supplementation on sexual function in men with T2D and mild-to-moderate erectile dysfunction (ED). Methods: Eighty men with T2D, suffering from mild-to-moderate erectile dysfunction participated in this double-blind clinical trial. They were randomly assigned in to two groups; receiving 5 g/day L-arginine (AG) or placebo group (PG) for 4 weeks. Sexual functions were recorded with international index of erectile function questionnaire at the beginning and end
of the intervention.
Total testosterone concentrations were measured too. Results: The total mean score of sexual function parameters significantly increased only in AG than PG (43.2 ± 6.2 vs. 39.4 ± 4.0, P = 0.003). Against PG, the mean of all parameters significantly improved in AG after intervention. Only the mean score of erectile function in AG had a significant increase compared to PG. Mean of other sexual activity scores between the two groups had no significant differences. The mean of testosterone concentration had a significant increase in both groups after the intervention, but the mean of changes was significantly higher in AG than in PG (1.91 μg/L vs. 0.53 μg/L, P = 0.004). Conclusions: The present trial showed that daily consumption of 5 g L-arginine for four weeks in T2D men with mild-to-moderate sexual dysfunction improved various parameters such as erectile function, sexual satisfaction, sexual desire, pleasure from sexual intercourse, and testosterone level.

Full-Text [PDF 431 kb]   (364 Downloads)    
Type of article: orginal article | Subject: public specific
Received: 2016/10/24 | Accepted: 2017/01/5 | Published: 2017/05/1

References
1. Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial. Iranian journal of psychiatry. 5 (1): 1.
2. Aoki H, et al. 2012. Clinical Assessment of a Supplement of Pycnogenolآ® and L-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction. Phytotherapy research. 26 (2): 204-207.
3. Aytac IA, McKinlay JB & Krane RJ 1999. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. British journal urological international. 84: 50-56.
4. Bacon CG, et al. 2002. Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes care. 25 (8): 1458-1463.
5. Chen J, et al. 1999. Effect of oral administration of high-dose nitric oxide donor l-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. British journal urological international. 83: 269-273.
6. Dadfar M, Taei K & Ebrahimpur A 2008. A study on the effectiveness of atorvastatin in the treatment of erectile dysfunction in hypercholesterolemic men Jundishapur medical journal. 7 (1): 110-112.
7. Enzlin P, Mathieu C, Van den Bruel A, Vanderschueren D & Demyttenaere K 2003. Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes care. 26 (2): 409-414.
8. Frank E, Anderson C & Rubinstein D 1978. Frequency of sexual dysfunction in normal couples. New England journal of medicine. 299 (3): 111-115.
9. Klotz T, Mathers MJ, Braun M, Bloch W & Engelmann U 1999. Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Urologia internationalis. 63 (4): 220-223.
10. Lamm S 2009. Preloxآ® for improvement of erectile quality. European journal of endocrinology. 5: 70-74.
11. Lebret T, Hervأ© J-M, Gorny P, Worcel M & Botto H 2002. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. European urology. 41 (6): 608-613.
12. Lewis RW 2001. Epidemiology of erectile dysfunction. Urologic clinics of north America. 28 (2): 209-216.
13. Mehraban D, Shabaninia SH, Naderi GH & Esfahani F 2006. Farsi international index of erectile dysfunction and doppler ultrasonography in the evaluation of male impotence. Iranian journal of surgery. 14 (1): 25-31.
14. Moody JA, Vernet D, Laidlaw S, Rajfer J & Gonzalez-Cadavid NF 1997. Effects of long-term oral administration of L-arginine on the rat erectile response. The journal of urology. 158 (3): 942-947.
15. Padma-Nathan H 2000. Hemodynamic effects of the oral administration of a combination of Arginine and Yohimbine measured by Color Duplex Ultrasonography in men with Erectile Dysfunction. In annual meeting of the European society for impotence research, poster.
16. Price D 2014. Sexual problems in diabetes. Medicine. 43 (1): 38-40.
17. Ratnasooriya WD, Dharmasiri MG & Wadsworth RM 2000. Reduction in libido and fertility of male rats by administration of the nitric oxide (NO) synthase inhibitor N-nitro-l-arginine methyl ester. International journal of andrology. 23 (3): 187-191.
18. Rush AJ & Blacker D 2008. Handbook of psychiatric measures. American Psychiatric Pub.
19. Santi D, et al. 2015. Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis. European journal of endocrinology. 172 (3): R103-114.
20. Thorve VS, et al. 2011. Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management. Journal of diabetes and its complications. 25 (2): 129-136.
21. World Health O 1996. Multiaxial classification of child and adolescent psychiatric disorders: the ICD-10 classification of mental and behavioural disorders in children and adolescents. Cambridge University Press.
22. Yasuda M, et al. 2008. Salivary 8-OHdG: A Useful Biomarker for Predicting Severe ED and Hypogonadism. The journal of sexual medicine. 5 (6): 1482-1491.