Volume 5, Issue 4 (Nov 2020)                   JNFS 2020, 5(4): 377-387 | Back to browse issues page


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Zare N, Eftekhari M H, Ghaem H, Dashtabi A. Effects of Zinc Supplementation on the Anthropometric Measurements, Leptin, Ghrelin and C-reactive protein in the Obese Adults with Increased Appetite and Baseline Zinc Deficiency: A Randomized Controlled Trial. JNFS. 2020; 5 (4) :377-387
URL: http://jnfs.ssu.ac.ir/article-1-270-en.html
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (374 Views)

 Background: Appetite is one of the main obesity-controlling factors that can be influenced by hormones, including leptin and ghrelin. This study aimed to determine the effects of zinc supplementation on the serum levels of leptin, ghrelin, C-reactive protein (CRP), and anthropometrical indices in obese individuals with increased appetite and zinc deficiency. Methods: This study was conducted among 50 individuals with body mass index > 30 kg/m2 in Shiraz, Iran in 2018. The participants were randomly allocated to the intervention that consumed one capsule containing 30 mg/day zinc (ZG) and placebo group (PG) for 3 months. Moreover, all participants were prescribed calorie-restricted diet, 500 kcal/d less than their weight maintenance requirement energy. Anthropometric indices, dietary intake, serum zinc leptin, ghrelin, and CRP were measured at the baseline and after the intervention. Results: The ccomparison of mean changes in weight (-4.56 ± 2.47, P < 0.0001), body mass index (-1.65 ± 0.85, P < 0.0001), waist circumference (-5.54 ± 4.06, P < 0.0001), hip circumference (-3.19 ±1.91, P < 0.0001), and serum zinc (15.91 ± 5.24, P < 0.0001) showed a significant difference between groups with greater reduction in the zinc group. However, waist to hip ratio, ghrelin, and CRP showed no significant differences. A significant difference was revealed between groups in terms of the mean leptin concentration changes, in favor of the increase in leptin concentration in ZG (P = 0.003). Conclusion: Based on the findings, three months of zinc supplementation improved some anthropometric and biochemical measures. Further studies are needed to confirm these results.

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Type of article: orginal article | Subject: public specific
Received: 2019/06/30 | Accepted: 2020/06/20 | Published: 2017/11/15 | ePublished: 2017/11/15

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