Background: Lipases are the most flexible biocatalysts and they catalyzes Bioconversion reactions wide range. These enzymes have beneficial effects on food substrates such as natural oils, synthetic triglycerides and fatty acids. Lipases are used in a wide range of modern biotechnology industries, such as the synthesis of biopolymers, biodiesel and the pharmaceutical industry in addition use in the food industry about to enrich the omega-3 fatty acid (Docosa hexaenoic acid) in soybean oil, processing of fats, dairy products and the development of food biosensors. Methods: Online databases such as PubMed, Scopus, ISI Web of Science, Google Scholar were searched without any restrictions. Results: The results of these studies show that due to the extraordinary potential of lipase In the food and medicine industry, codification a strategic plan in the country, To develop mass production technologies for these enzymes and Practical steps, It seems necessary in their use in essential food enrichment. Conclusions: Characteristics of the use of lipase catalytic reactions have a significant commercial potential in industrial biotechnology. The production of these enzymes in the industry has a significant commercial potential in industrial biotechnology.