Volume 3, Issue 2 (May 2018)                   JNFS 2018, 3(2): 106-112 | Back to browse issues page

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Goodarzi S, Rafiei S, Javadi M, Khadem Haghighian H, Noroozi S. A Review on Antioxidants and Their Health Effects. JNFS 2018; 3 (2) :106-112
URL: http://jnfs.ssu.ac.ir/article-1-158-en.html
Department of Nutrition, School of Public Health, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract:   (3306 Views)
Background: Literature has focused that oxidative damage is a common factor in the aging process and the formation and development of major diseases. Such a finding encouraged the use of antioxidants to prevent and treat mentioned problems. Several research endeavors have done on the issue to find out any relevant relationship between antioxidant use and human being health especially in the case of preventing premature aging and many kinds of diseases. This study outlines results of representative research studies conducted worldwide to clarify the necessity of antioxidant use in health promotion of human life. Methods: For the purpose a literature review was done through defining an appropriate search strategy to identify existing evidence and key publications on the issue. Results: Study findings revealed that existing literature is not enough to prove the antioxidant usefulness for improving human health outcomes and it seems that other factors including life style should also be considered instead of focusing on isolated antioxidants as single leading factors. Conclusions: It is necessary to obtain comprehensive information from the influencing factors including disease origins, diet and different environmental, individual factors to determine possible effects on health condition or survival.
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Type of article: review article | Subject: public specific
Received: 2018/05/1 | Published: 2018/05/1 | ePublished: 2018/05/1

References
1. Al-Asmari A, Khan A, Al-Asmari S, Al-Rawi A & Al-Omani S 2016. Alleviation of 5-fluorouracil-induced intestinal mucositis in rats by vitamin E via targeting oxidative stress and inflammatory markers. Journal of complementary and integrative medicine. 13 (4): 377-385.
2. Alin J & Hakkarainen M 2011. Microwave heating causes rapid degradation of antioxidants in polypropylene packaging, leading to greatly increased specific migration to food simulants as shown by ESI-MS and GC-MS. Journal of agricultural and fFood chemistry. 59 (10): 5418-5427.
3. Bahadoran Z, Mirmiran P & Azizi F 2013. The role of dietary polyphenols in reducing cardiovascular complications in type 2 diabetes: A review of studies. Journal of pejouhandeh. 18 (1): 1-7.
4. Bahmani F, Kia M, Soleimani A, Mohammadi A & Asemi Z 2016. The effects of selenium supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy: a randomised, double-blind, placebo-controlled trial. British journal of nutrition. 116 (7): 1222-1228.
5. Bardia A, et al. 2008. Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: systematic review and meta-analysis. Mayo Clinic Proceedings (83): 23-34.
6. Bjelakovic G, Nikolova D & Gluud C 2013. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 8 (9): e74558.
7. Bjelakovic G, Nikolova D & Gluud C 2014. Antioxidant supplements and mortality. Current opinion clinica nutrition & metabolic care. 17 (1): 40-44.
8. Briançon S, et al. 2011. Long-term antioxidant supplementation has no effect on health-related quality of life: The randomized, double-blind, placebo-controlled, primary prevention SU. VI. MAX trial. International journal of epidemiology. 40 (6): 1605-1616.
9. Chen J 2012. An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). Asian pacific journal of clinical nutrition. 21: 320-323.
10. Cheng K, et al. 2017. Effects of dietary vitamin E type on the growth performance and antioxidant capacity in cyclophosphamide immunosuppressed broilers. Poultry science. 96 (5): 1159-1166.
11. Cook N, et al. 2007. A Randomized Factorial Trial of Vitamins C, E, and Beta-Carotene in the Secondary Prevention of Cardiovascular Events in Women. Archives of internal medicine. 167 (15): 1610-1618.
12. Davì G, Falco A, Patrono C & 2005;7:256–268 ARS 2005. Lipid peroxidation in diabetes mellitus. Antioxidants & redox signaling. 7 (1-2): 256-268.
13. El-Shafei R & Saleh RP- 2016. Pharmacological effects of Vitamin C & E on Diclofenac Sodium intoxicated Rats. Biomedicine & pharmacotherapy. 84: 314-322.
14. Finley J, et al. 2011. Antioxidants in foods: state of the science important to the food industry. Journal of agricultural and food chemistry. 59 (13): 6837–6846.
15. Gaziano J, et al. 2009. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. Journal of the american medical association. 301 (1): 52-62.
16. Ghorbel I, et al. 2017. Selenium Alleviates Oxidative Stress and Lung Damage Induced by Aluminum Chloride in Adult Rats: Biochemical and Histological Approach. Biological trace element research. 176 (1): 181-191.
17. Goodman G, et al. 2004. The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. Journal of national cancer institute. 96 (23): 1743-1750.
18. Hitchon C & El-Gabalawy H 2004. Oxidation in rheumatoid arthritis. Arthritis research and therapy. 6: 265-278.
19. Klein E, et al. 2011. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Journal of the American medical association. 306 (14): 1549-1556.
20. Lai G, et al. 2014. Effects of α-tocopherol and β-carotene supplementation on liver cancer incidence and chronic liver disease mortality in the ATBC study. British journal of cancer. 111 (12): 2220-2223.
21. Langseth L 1995. Oxidants, antioxidants and disease prevention. JLSI Europe: Brussels, Belgium.
22. Lee I, et al. 2005. Vitamin E in the primary prevention of cardiovascular disease and cancer.The women's health study: a randomized controlled trial. Journal of the American medical association.(294): 56-65.
23. Lee I, Cook N, Manson J, Buring J & Hennekens C 1999. Beta-carotene supplementation and incidence of cancer and cardiovascular disease.The women's health study. Journal of natl cancer institution.(91): 2102-2106.
24. Leopold J 2015. Antioxidants and Coronary Artery Disease: From Patho-physiology to Preventive Therapy. Coronary artery disease 26 (2): 176–183.
25. Lippman S, et al. 2009. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Journal of the American medical association. 301 (1): 39-51.
26. Moser M & Chun O 2016. Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies. International journal of molecular sciences. 17 (8): 1328.
27. Mousa N, et al. 2016. The role of antioxidants and zinc in minimal hepatic encephalopathy: a randomized trial. Therapeutic advances in gastroenterolog. 9 (5): 684 –691.
28. Nunomura A, et al. 2006. Involvement of oxidative stress in Alzheimer disease. Journal of neuropathology & experimental neurology. 65 (7): 631-641.
29. Paganini-Hill a, Kawas C & MM. C 2015. Antioxidant Vitamin Intake and Mortality. American journal of epidemiology. 181 (2): 120-126.
30. Pham-Huy L, He H & Pham-Huy C 2008. Free Radicals, Antioxidants in Disease and Health. InternatIonal journal of biomedical science. 4 (2): 89-97.
31. Sesso H, et al. 2008. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. Journal of the American medical association. 300 (18): 2123-2133.
32. Sil S, et al. 2016. Dual Role of Vitamin C on the Neuroinflammation Mediated Neurodegeneration and Memory Impairments in Colchicine Induced Rat Model of Alzheimer Disease. Journal of molcular neuroscience. 60 (4): 421-435.
33. Stepaniak U, Micek A, Grosso G & Stefler D 2016. Topor-Madry R, Kubinova R, et al. Antioxidant vitamin intake and mortality in three Central and Eastern European urban populations: the HAPIEE study. European journal of nutrition. 55 (2): 547-560.
34. Taherdehi F, Nikravesh M, Jalali M & Fazel A 2016. Evaluating the protective effects of vitamin C on serum and erythrocyte cholinesterase activity of male rats exposed to malathion. Electronic physician. 8 (7): 2633.
35. Tamimi R, et al. 2005. Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. American journal of epidemiology 161 (2): 153-160.
36. Valko M, et al. 2007. Free radicals and antioxidants in normal physiological functions and human disease. International journal of biochemistry and cell biology. 39: 44-84.
37. Vertuani S, Angusti A & Manfredini S 2004. The antioxidants and pro-antioxidants network: an overview. Current pharmaceutical design. 10 (14): 1677-1694.
38. Wang L, et al. 2014. Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians' Health Study II randomized trial. American journal of clinical nutrition. 100 (3): 915-923.
39. Waters D, et al. 2002. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in post-menopausal women: a randomized controlled trial. Journal of the American medical association.(288): 2432-2440.
40. Wiseman H 1993. Vitamin D is a membrane antioxidant. Ability to inhibit iron dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. Federation of furopean biochemical societies (FEBS). 326 (1-3): 285-288.
41. Yasueda A, Urushima H & Ito T 2016. Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review. Integrated cancer therapies. 15 (1): 17-39.
42. Zhou C, et al. 2016. Dietary Vitamin C Intake Reduces the Risk of Type 2 Diabetes in Chinese Adults: HOMA-IR and T-AOC as Potential Mediators. PLoS One. 11 (9): e0163571.

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