Volume 4, Issue 2 (May 2019)                   JNFS 2019, 4(2): 83-92 | Back to browse issues page

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Khosravi M, Raisi F, Hosseinzadeh M, Golzar M, Majdzadeh R, Sotoudeh G. Comparison between Macro & Micro Nutrient Intake in Depressed Patients with Healthy People. JNFS. 2019; 4 (2) :83-92
URL: http://jnfs.ssu.ac.ir/article-1-254-en.html
Abstract:   (53 Views)
Background: In recent years, the prevalence of depression has grown dramatically in the world. According to WHO reports, about 350 million people suffer from depression. In addition to the side effects of antidepressants, many patients are resistant to treatment with these drugs. One of the most important effective factors in the pathology of depression is the role of nutrition in controlling and preventing this disease. Therefore, the aim of this study was to investigate the macronutrient and micronutrient status in depressed patients and compare them with healthy people.  Methods: In this case-control study, 110 depressed patients were matched with 220 healthy controls based on their age, gender, and area of residence. Patients were selected by simple sampling method. In the case group, unipolar major depressive disorder was diagnosed by a psychiatrist using the DSM-IV criteria. Food intakes of all participants were obtained using reliable semi-quantitative food frequency questionnaires and analyzed with Nutritionist4 software. Anthropometric measurements including height, weight, and waist circumference were calculated for all participants.  Results: The participants included 260 women and 71 men. The two groups had a statistically significant difference in terms of occupation, history of depression, childhood traumatic experiences, and family history of depression (P < 0.05). Regarding the macronutrients and micronutrients, a significant difference was observed between the case and control groups in terms of vitamin C, vitamin K, and dietary fiber intake, which were lower in depressed patients. Conclusion: The results of this study indicated that intake of some micronutrients such as vitamins C, K, and dietary fiber may be associated with an increased risk of depression. Consumption of some micronutrients, mainly fruits and vegetables may be effective to control or prevent the risk of depression.
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Type of article: orginal article | Subject: public specific
Received: 2018/02/17 | Accepted: 2018/07/14 | Published: 2019/05/1

1. Aadahl M & Jorgensen T 2003. Validation of a new self-report instrument for measuring physical activity. Medicine & science in sports & exercise. 35 (7): 1196-1202.
2. Barnes A 1994. Diagnostic and statistical manual mental of disorders: DSM-IV. Shahed university publications: Tehran.
3. Beydoun MA, et al. 2015. Associations of the Ratios of n-3 to n-6 Dietary Fatty Acids With Longitudinal Changes in Depressive Symptoms Among US Women. American journal of epidemiology. 181 (9): 691-705.
4. Beydoun MA, et al. 2010. The sex-specific role of plasma folate in mediating the association of dietary quality with depressive symptoms. Journal of nutrition. 140 (2): 338-347.
5. Blunden CH, et al. 2012. Postpartum depressive symptoms: the B-vitamin link. Mental health in family medicine. 9 (1): 5-13.
6. Bourre JM 2006. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. Journal of nutrition health and aging. 10 (5): 377-385.
7. Cole MG & Dendukuri N 2003. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. American journal of psychiatry. 160 (6): 1147-1156.
8. Coppen A & Bolander-Gouaille C 2005. Treatment of depression: time to consider folic acid and vitamin B12. Journal of psychopharmacology. 19 (1): 59-65.
9. Davidson K, Jonas BS, Dixon KE & Markovitz JH 2000. Do depression symptoms predict early hypertension incidence in young adults in the CARDIA study? Coronary Artery Risk Development in Young Adults. Archives of internal medicine. 160 (10): 1495-1500.
10. Duntas LH, Mantzou E & Koutras DA 2003. Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. European journal of endocrinology. 148 (4): 389-393.
11. Frusciante L, et al. 2007. Antioxidant nutritional quality of tomato. Molecular nutrition & food research. 51 (5): 609-617.
12. Gea A, Martinez-Gonzalez, M.A., Toledo, E., Sanchez-Villegas, A., Bes-Rastrollo, M., Nuñez-Cordoba, J.M., Sayon-Orea, C. and Beunza, J.J., 2012. A longitudinal assessment of alcohol intake and incident depression: the SUN project. . BMC public health. 12 (1): 954.
13. Goncalves DM, Stein AT & Kapczinski F 2008. Performance of the Self-Reporting Questionnaire as a psychiatric screening questionnaire: a comparative study with Structured Clinical Interview for DSM-IV-TR. Cadernos de saude publica. 24 (2): 380-390.
14. Hodgson K, Tansey, K.E., Uher, R., Dernovšek, M.Z., Mors, O., Hauser, J., Souery, D., Maier, W., Henigsberg, N., Rietschel, M. and Placentino, A., 2015. Exploring the role of drug-metabolising enzymes in antidepressant side effects. Psychopharmacology. 232 (14): 2609-2617.
15. Hou SJ, Yen FC & Tsai SJ 2009. Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease? Mededical hypotheses. 72 (2): 166-168.
16. Kaner G, et al. 2015. Evaluation of nutritional status of patients with depression. BioMed research international. 2015: 521481.
17. Kelishadi R, et al. 2004. Assessment of physical activity in adolescentsof Isfahan. Sharekord University Of Medical Sciences Journal {persian}. 3: 55-65.
18. Kim NR, Kim KW, Kim HN & Song SW 2018. Associations Between Serum Zinc Levels and Mental Health: Findings from the 2010 Korean National Health and Nutrition Examination Survey. Biological trace element research. 181 (2): 192-198.
19. Kuczmarski MF, et al. Higher Healthy Eating Index-2005 scores associated with reduced symptoms of depression in an urban population: findings from the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study. Journal of the American dietetic association. 110 (3): 383-389.
20. Kyrozis A, et al. 2009. Dietary lipids and geriatric depression scale score among elders: the EPIC-Greece cohort. Journal of psychiatric research. 43 (8): 763-769.
21. Miki T, et al. 2016. Dietary fiber intake and depressive symptoms in Japanese employees: The Furukawa Nutrition and Health Study. Nutrition (Burbank, Los Angeles County, Calif.). 32 (5): 584-589.
22. Miller A 2008. The methylation, neurotransmitter, and antioxidant connections between folate and depression. Alternative medicine review. 13 (3): 216-226.
23. Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M & Azizi F 2010. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public health nutrition. 13 (5): 654-662.
24. Payne ME, et al. 2009. Natural food folate and late-life depression. Journal of nutrition for the elderly. 28 (4): 348-358.
25. Payne ME, Steck SE, George RR & Steffens DC 2012. Fruit, vegetable, and antioxidant intakes are lower in older adults with depression. Journal of the Academy of Nutrition and Dietetics. 112 (12): 2022-2027.
26. Prohan M, Amani R, Nematpour S, Jomehzadeh N & Haghighizadeh MH 2014. Total antioxidant capacity of diet and serum, dietary antioxidant vitamins intake, and serum hs-CRP levels in relation to depression scales in university male students. Redox Report. 19 (3): 133-139.
27. Rubio-Lopez N, Morales-Suarez-Varela M, Pico Y, Livianos-Aldana L & Llopis-Gonzalez A 2016. Nutrient Intake and Depression Symptoms in Spanish Children: The ANIVA Study. International journal of environmental research and public health. 13 (3): 352-365.
28. Sanchez-Villegas A, et al. 2012. Fast-food and commercial baked goods consumption and the risk of depression. Public health nutrition. 15 (3): 424-432.
29. Solfrizzi V, et al. 2006. Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian longitudinal study on aging. Neurobiology of aging 27 (11): 1694-1704.
30. Stoll AL, et al. 1999. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Archives of general psychiatry. 56 (5): 407-412.
31. Tsai SJ 2006. The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression. Medical hypotheses. 66 (2): 319-322.
32. Tsai SJ 2007. The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants. Medical hypotheses. 68 (1): 180-183.
33. Wells AS, Read NW, Laugharne JD & Ahluwalia NS 1998. Alterations in mood after changing to a low-fat diet. British journal nutrition. 79 (1): 23-30.
34. World health organization 2018. Depression WHO: https://www.who.int/en/news-room/fact-sheets/detail/depression

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